COMPARISON OF THE EFFICACY OF GABAPENTIN AND PREGABALIN FOR NEUROPATHIC PAIN IN PATIENTS WITH SPINAL CORD INJURY: A CROSSOVER STUDY

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dc.contributor.authorKaydok, Ercan
dc.contributor.authorLevendoglu, Funda
dc.contributor.authorOzerbil, Murat Onder
dc.contributor.authorKarahan, Ali Yavuz
dc.date.accessioned2020-03-26T18:49:50Z
dc.date.available2020-03-26T18:49:50Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjectives: To compare the efficacy and Side effects of gabapentin and pregabalin for the treatment of neuropathic pain(NP) in spinal cord injury (SCI). Methods: Twenty eight patients were included in the study. The patients were randomized to receive pregabalin or gabapentin. VAS(Vistial analog scak) pain score, neuropathie pain scale(NPS), Lattinen test(LT), Beck Depression Inventory(BDI) pain diary measures were used for the patient evaluation. We assessed patients at 4th and 8th weeks.Treatment groups were crOssed over after 2 weeks of wash-out period to receive the other treatment. Results: At the end of the study there: was significant improvement in VAS both with gabapentin and pregabalin (p<0.001). Statistically significant difference was present during the first 4 weeks in the asSessinent with VAS as for pregabalin group compared to gabapentin group(p<0.05). But after 8 weeks of treatments the significance disappeared between the pregabalin and the gabapentin groups (p>0.05). In NPS, and LT parameters, no difference was present between the two study groups before or after the treatment (p>0.05). In both groups no significant improvement was seen in emotional status as assessed with BD (p>0.05). Frequency of side effects and exclusion from the study due to side effects were higher for the pregabalin group but it was not significant between the groups (p>0.05). Conclusions: It is concluded that both drugs are effective and safe for the treatment of NP due to SC1 but no difference exist between the two drugs. We are in the opinion that large studies that include more patients and placebo control should be carried out for more accurate data about this topic.en_US
dc.identifier.endpage1348en_US
dc.identifier.issn0393-6384en_US
dc.identifier.issn2283-9720en_US
dc.identifier.issue6en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1343en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30695
dc.identifier.volume30en_US
dc.identifier.wosWOS:000364114900029en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherCARBONE EDITOREen_US
dc.relation.ispartofACTA MEDICA MEDITERRANEAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectSpinal cord injuryen_US
dc.subjectneuropathic painen_US
dc.subjectgabapentinen_US
dc.subjectpregabalinen_US
dc.titleCOMPARISON OF THE EFFICACY OF GABAPENTIN AND PREGABALIN FOR NEUROPATHIC PAIN IN PATIENTS WITH SPINAL CORD INJURY: A CROSSOVER STUDYen_US
dc.typeArticleen_US

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