EFFECT OF MORCHELLA CONICA AND FOMES FOMENTARIUS EXTRACTS AGAINST THE HUMAN RESPIRATORY SYNCYTIAL VIRUS IN-VITRO
Küçük Resim Yok
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
INT JOURNAL PHARMACEUTICAL SCIENCES & RESEARCH
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Antiviral properties of methanol and aqueous extracts from Morchella conica and Fomes fomentarius were assessed by colorimetric XTT test against human respiratory syncytial virus (HRSV). HEp-2 cell line was used for the cytotoxic and antiviral effects of the extracts. Non-cytotoxic concentrations of methanol and aqueous extracts of M. conica were tested in 50000 to 195 mu g/mL. In contrast, the cytotoxic F. fomentarius methanol and aqueous extracts and Ribavirin were tested at concentrations from 3347-13.1 mu g/mL, 4906.5-19.2 mu g/mL and 86.60-0.30 mu g/mL, respectively. The results showed that aqueous extract of F. fomentarius had strong anti-HRSV activity (EC50 = 358.7 mu g/mL, SI = 27.4) which could be compared with ribavirin (EC50 = 15.6 mu g/mL, SI = 11.1) used as a positive control against HRSV, while other extracts (M. conica methanol extract EC50 = 28055 mu g/mL, SI = >1.8; F. fomentarius methanol extract EC50 = 3000 mu g/mL, SI = 2.2) were found to have weak antiviral activity. As a result, it can be said that aqueous extract of F. fomentarius is worthy of further study as an alternative drugs in order to develop anti RSV.
Açıklama
Anahtar Kelimeler
Morchella conica, Fomes fomentarius, Methanolic and aqueous extracts, Antiviral activity, Respiratory syncytial virus
Kaynak
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
9
Sayı
12
