EFFECT OF MORCHELLA CONICA AND FOMES FOMENTARIUS EXTRACTS AGAINST THE HUMAN RESPIRATORY SYNCYTIAL VIRUS IN-VITRO

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dc.contributor.authorDogan, Hasan Huseyin
dc.contributor.authorDuman, Rustem
dc.contributor.authorTuncer, Pinar
dc.date.accessioned2020-03-26T19:53:34Z
dc.date.available2020-03-26T19:53:34Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAntiviral properties of methanol and aqueous extracts from Morchella conica and Fomes fomentarius were assessed by colorimetric XTT test against human respiratory syncytial virus (HRSV). HEp-2 cell line was used for the cytotoxic and antiviral effects of the extracts. Non-cytotoxic concentrations of methanol and aqueous extracts of M. conica were tested in 50000 to 195 mu g/mL. In contrast, the cytotoxic F. fomentarius methanol and aqueous extracts and Ribavirin were tested at concentrations from 3347-13.1 mu g/mL, 4906.5-19.2 mu g/mL and 86.60-0.30 mu g/mL, respectively. The results showed that aqueous extract of F. fomentarius had strong anti-HRSV activity (EC50 = 358.7 mu g/mL, SI = 27.4) which could be compared with ribavirin (EC50 = 15.6 mu g/mL, SI = 11.1) used as a positive control against HRSV, while other extracts (M. conica methanol extract EC50 = 28055 mu g/mL, SI = >1.8; F. fomentarius methanol extract EC50 = 3000 mu g/mL, SI = 2.2) were found to have weak antiviral activity. As a result, it can be said that aqueous extract of F. fomentarius is worthy of further study as an alternative drugs in order to develop anti RSV.en_US
dc.description.sponsorshipSelcuk University, Scientific Research Projects Coordinating OfficeSelcuk University [SU-BAP-14401086]en_US
dc.description.sponsorshipThe authors would like to thank Selcuk University, Scientific Research Projects Coordinating Office (SU-BAP-14401086) for the project funding.en_US
dc.identifier.doi10.13040/IJPSR.0975-8232.9(12).5240-45en_US
dc.identifier.endpage5245en_US
dc.identifier.issn0975-8232en_US
dc.identifier.issue12en_US
dc.identifier.pmid#YOKen_US
dc.identifier.startpage5240en_US
dc.identifier.urihttps://dx.doi.org/10.13040/IJPSR.0975-8232.9(12).5240-45
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36537
dc.identifier.volume9en_US
dc.identifier.wosWOS:000451885300025en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherINT JOURNAL PHARMACEUTICAL SCIENCES & RESEARCHen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectMorchella conicaen_US
dc.subjectFomes fomentariusen_US
dc.subjectMethanolic and aqueous extractsen_US
dc.subjectAntiviral activityen_US
dc.subjectRespiratory syncytial virusen_US
dc.titleEFFECT OF MORCHELLA CONICA AND FOMES FOMENTARIUS EXTRACTS AGAINST THE HUMAN RESPIRATORY SYNCYTIAL VIRUS IN-VITROen_US
dc.typeArticleen_US

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