Mesoporous silica and chitosan based pH-sensitive smart nanoparticles for tumor targeted drug delivery

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dc.contributor.authorDeveci, Pervin
dc.contributor.authorTaner, Bilge
dc.contributor.authorAlbayati, Safaa Hashim Mohammed
dc.date.accessioned2020-03-26T19:42:04Z
dc.date.available2020-03-26T19:42:04Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAlthough various therapies have been developed for cancer treatment, chemotherapy plays a vital role, but still faces many challenges, such as severe cytotoxicity, side effects, multidrug resistance, and poor tumor selectivity. The development of targeted drug delivery has provided new strategies for addressing the limitations of the conventional chemotherapy, and has become more significant in clinical research in recent times. Among the various stimuli, pH triggered delivery is regarded as the most general strategy, targeting the acidic extracellular microenvironment and intracellular organelles of solid tumors. It is well-known that the extracellular pH of most tumor tissues is more acidic (pH 6.5-6.8) than that of normal tissues (pH 7.4). In our present review, we focus on some of the recent literature reports on the fabrication and application of pH-sensitive smart nanoparticles for tumor targeted drug delivery system. The strategies to the chemical design of these nanocarriers and their clinical findings are discussed. Particular focus is given to silica, chitosan, and silica-chitosan based nanocarriers. These smart nanoparticles will have a promising platform in improving human health and quality of life.en_US
dc.identifier.doi10.1007/s10847-017-0741-5en_US
dc.identifier.endpage27en_US
dc.identifier.issn1388-3127en_US
dc.identifier.issn1573-1111en_US
dc.identifier.issue01.02.2020en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage15en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s10847-017-0741-5
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35286
dc.identifier.volume89en_US
dc.identifier.wosWOS:000411121500002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofJOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRYen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectNanoparticlesen_US
dc.subjectMesoporous silicaen_US
dc.subjectChitosanen_US
dc.subjectTargeted cancer therapyen_US
dc.subjectDoxorubicinen_US
dc.titleMesoporous silica and chitosan based pH-sensitive smart nanoparticles for tumor targeted drug deliveryen_US
dc.typeReviewen_US

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