Alterations of Serum Leptin Levels in Patients With Nonalcoholic Liver Cirrhosis

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dc.contributor.authorKayaçetin, Ertuğrul
dc.contributor.authorKısakol, Gürcan
dc.contributor.authorGönen, Sait
dc.contributor.authorDikbaş, Oğuz
dc.contributor.authorGüngör, Kağan
dc.contributor.authorKayaçetin, Serra
dc.contributor.authorTopcu, Cemile
dc.contributor.authorKaya, Ahmet
dc.date.accessioned2020-03-26T17:03:00Z
dc.date.available2020-03-26T17:03:00Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn liver cirrhosis, nutritional status is quite impaired, and the current data has shown conflicting results in serum leptin levels of cirrhotic patients. In this study, we aimed to evaluate serum leptin levels in nonalcoholic liver cirrhosis and determine its relationship with anthropometric parameters and liver function. Thirty-three patients (13 males, 20 females) with nonalcoholic cirrhosis and 16 (9 males, 7 females) healthy control subjects were recruited for this study. Serum leptin values were measured in morning samples of both groups by enzyme-linked immunosorbent assay. The mean levels of leptin were not different in nonalcoholic cirrhotic patients when compared with the control group (P = 0.478). Serum leptin values were positively correlated with prothrombin (international normalized ratio) (P = 0.008, r = 0.64) and total bilirubin (P = 0.047, r = 0.488) and were negatively correlated with high-density lipoprotein (P = 0.025, r = 0.666) and albumin (P = 0.009, r = 0.615). No correlation was found between leptin levels and severity of the liver disease. These findings suggest leptin levels do not depend on the degree of liver damage in patients with nonalcoholic cirrhosis of the liver.en_US
dc.identifier.citationKayaçetin, E., Kısakol, G., Gönen, S., Dikbaş, O., Güngör, K., Kayaçetin, S., Topcu, C., Kaya, A., (2006). Alterations of Serum Leptin Levels in Patients With Nonalcoholic Liver Cirrhosis. The Endocrinologist, 16(2), 61-63. Doi: 10.1097/01.ten.0000202689.95052.66
dc.identifier.doi10.1097/01.ten.0000202689.95052.66en_US
dc.identifier.endpage63en_US
dc.identifier.issn1051-2144en_US
dc.identifier.issn1539-9192en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage61en_US
dc.identifier.urihttps://dx.doi.org/10.1097/01.ten.0000202689.95052.66
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20313
dc.identifier.volume16en_US
dc.identifier.wosWOS:000236381000003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorGönen, Sait
dc.institutionauthorDikbaş, Oğuz
dc.institutionauthorGüngör, Kağan
dc.institutionauthorKayaçetin, Serra
dc.institutionauthorTopcu, Cemile
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofThe Endocrinologisten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectHepatic functionen_US
dc.subjectVariceal bleedingen_US
dc.subjectHemodynamicsen_US
dc.titleAlterations of Serum Leptin Levels in Patients With Nonalcoholic Liver Cirrhosisen_US
dc.typeArticleen_US

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