The role of thrombomodulin in the increased tendency of hypercoagulability in patients treated with cisplatin based chemotherapy

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dc.contributor.authorBoruban, M. Cem
dc.contributor.authorOnur, Handan
dc.date.accessioned2020-03-26T17:28:15Z
dc.date.available2020-03-26T17:28:15Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractOne of the reason why chemotherapeutics cause increased intencity to coagulation may be the endotelial damage. The exact mechanism is not known clearly. Trombomodulin is an important modulater of inravascular coagulation and is available on many of the endotelial, tumors. In this study the effect of F-VIII, vWF other coagulation factors and thrombomoduline in the increased coagulation due to vasculary toxicity and endothelial damage after cisplatin administration were evalutaed. Venous blood samples were taken from the patients before treatment and between 12 and 24 hours after treatment. PT, aPTT, TT, fibrinojen, D-Dimer, F-VIII and thrombomodulin levels were measured. TM levels before and after chemotherapy were measured in 27 of 28 patients. Mean TM level before treatment (TMBT) was 47.7 +/- 24.8 ng/ml (22-130 ng/ml) and mean TM level after treatment (TMAT) was 39.7 +/- 19.5 ng/ml (18-96 ng/ml). The difference was not significant. The diffrence of pre and post treatment levels of TT (P=0.02) and fibrinogen (P=0.005) were significant. The researches with more patients included, may reveal TM level as a sign of endothelial toxicity. The expacted changes in the parameters after treatment were not significant as thought to be related with the inadequate number of patients.en_US
dc.identifier.endpage92en_US
dc.identifier.issn1306-133Xen_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage85en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22744
dc.identifier.volume18en_US
dc.identifier.wosWOS:000258507500004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherAKAD DOKTORLAR YAYINEVIen_US
dc.relation.ispartofUHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISIen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectthrombomodulinen_US
dc.subjectcisplatinen_US
dc.subjectcoagulationen_US
dc.subjectendothelium and toxicityen_US
dc.titleThe role of thrombomodulin in the increased tendency of hypercoagulability in patients treated with cisplatin based chemotherapyen_US
dc.typeArticleen_US

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