Comparison of virulence factors and antibiotic resistance of Pseudomonas aeruginosa strains isolated from patients with and without cystic fibrosis

Basit Öğe Kaydı
dc.contributor.authorMaçin, Salih
dc.contributor.authorAkarca, Meral
dc.contributor.authorŞener, Burçin
dc.contributor.authorAkyön, Yakut
dc.date.accessioned2020-03-26T19:34:32Z
dc.date.available2020-03-26T19:34:32Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIts rising incidence, virulence factors and antibiotic resistance rate makes it difficult to treat Pseudomonas aeruginosa infections. The aim of this study was to compare virulence factors and antibiotic resistance of P. aeruginosa isolates from cystic fibrosis (CF) and other lower respiratory tract infections. Isolates from patients (n=125) were divided into two groups. The isolates in the first group were from CF patients (n=64). And in the other group isolates were from lower respiratory tract samples, from patients that did not have CF (n=61). The antibiotic susceptibility tests were done by using disc diffusion method. As phenotypic tests; DNase, protease, elastase, hemolysis, and motility test were performed. The mucoid form of P. aeruginosa was detected in 29.7% of CF patients' isolates, whereas in the other group (non-CF) this rate was 9.8% (p=0.011). Motility in the CF patients' isolates was lower (84.4%) then the other group (96.7%). The presence of DNase was significantly low in CF patients' isolates when compared to the other group (p=0.009). When the antibiotic resistance was compared; ceftazidime, imipenem and meropenem and piperacillin resistance was found significantly low in CF patients compared to isolates from the other group (p=0.05). Information about virulence factor patterns and antibiotic resistance of P. aeruginosa isolates from patients with cystic fibrosis and the patients without cystic fibrosis can prevent the unnecessary usage of antibiotics and lead the way to new approaches in treatment..en_US
dc.identifier.doi10.1515/rrlm-2017-0027en_US
dc.identifier.endpage334en_US
dc.identifier.issn1841-6624en_US
dc.identifier.issn2284-5623en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage327en_US
dc.identifier.urihttps://dx.doi.org/10.1515/rrlm-2017-0027
dc.identifier.urihttps://hdl.handle.net/20.500.12395/34912
dc.identifier.volume25en_US
dc.identifier.wosWOS:000417164200002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUNIV PRESSen_US
dc.relation.ispartofREVISTA ROMANA DE MEDICINA DE LABORATORen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAntibiotic susceptibilityen_US
dc.subjectCystic fibrosisen_US
dc.subjectPseudomonas aeruginosaen_US
dc.subjectvirulenceen_US
dc.titleComparison of virulence factors and antibiotic resistance of Pseudomonas aeruginosa strains isolated from patients with and without cystic fibrosisen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu