Interaction of L-myc oncogene in breast cancer with irinotecan onto functionalized magnetic nanoparticles

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dc.contributor.authorMaltas, Esra
dc.contributor.authorOzmen, Mustafa
dc.contributor.authorVural, Hasibe Cingilli
dc.date.accessioned2020-03-26T18:42:12Z
dc.date.available2020-03-26T18:42:12Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe effect of different functional groups on binding capacity of DNA was studied with bare and modified superparamagnetic iron oxide nanoparticles (SPIONs). For this purpose, modifications were performed with [3(2,3-epoxypropoxy)propyl] trimethoxy silane (GPTS) and (3-aminopropyl) triethoxysilane (APTS) by silanization reaction and also subsequent reaction with glutaraldehyde (GA) to obtain functional groups on nanoparticles surface. L-myc gene from breast tissue with cancer was amplified by using polymerase chain reaction (PCR). APTS functionalized nanoparticles showed the highest binding capacity (82.70%) when compared with bare, GPTS, APTS and GA functionalized SPIONs. DNA immobilized magnetic nanoparticles were also examined by Scanning Electron Microscopy. Binding capacity of irinotecan to DNA onto SPIONs was found as 2.81 x 10(-5) mg/mL for 20 mg of APTS modified nanoparticles by using fluorescence spectroscopy. (C) 2013 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipResearch Foundation of Selcuk University (BAP)Selcuk Universityen_US
dc.description.sponsorshipWe would like to thank the Research Foundation of Selcuk University (BAP) for financial support of this work.en_US
dc.identifier.doi10.1016/j.matlet.2013.05.008en_US
dc.identifier.endpage10en_US
dc.identifier.issn0167-577Xen_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage8en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.matlet.2013.05.008
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29576
dc.identifier.volume106en_US
dc.identifier.wosWOS:000322682500003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofMATERIALS LETTERSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectDNAen_US
dc.subjectIrinotecanen_US
dc.subjectLuminescenceen_US
dc.subjectMagnetic materialsen_US
dc.subjectSilanizationen_US
dc.titleInteraction of L-myc oncogene in breast cancer with irinotecan onto functionalized magnetic nanoparticlesen_US
dc.typeArticleen_US

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