Evaluation of TGF betal expression and comparison the thickness of different aorta layers in experimental diabetes

Basit Öğe Kaydı
dc.contributor.authorCuce, G.
dc.contributor.authorKalkan, S. S.
dc.contributor.authorEsen, H. H.
dc.date.accessioned2020-03-26T18:14:35Z
dc.date.available2020-03-26T18:14:35Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: It was aimed to investigate the effects of experimental diabetes on TGF beta 1 expression and tunica intima and media thickness in abdominal and thoracic aorta. Methods: Fourteen three months old female rats were divided into two groups, non-diabetic and streptozotocin (STZ) induced diabetic group. Hematoxylin-Eosin and Verhoeff's Van Gieson elastic staining and TGF beta 1 immunohistochemistry staining were performed. Abdominal and thoracic intima and media thickness of aortas were measured with the oculometer. Results: Evaluation of intima and media thickness measurements showed no significant statistical differences between non-diabetic and diabetic groups. TGF beta 1 expression increased significantly in thoracic diabetic (TD) group. Conclusion: The 60 day duration of diabetes is not sufficiently enough time for the development of pathological changes that could lead to thickening in aortic intima-media layers. TGF beta 1 expression was negative in the abdominal aorta that can predispose to the development of atherosclerosis, which could develop overtime. This finding may be interpreted as an appropriate basis for the development of atherosclerosis. In the thoracic aorta TGF beta 1 may coordinate cellular events such as tissue repair (Fig. 5, Ref. 23). Full Text in free PDF www.bmj.sk.en_US
dc.description.sponsorshipSelcuk UniversitySelcuk University [BAP 09202041]en_US
dc.description.sponsorshipThis research was supported by the Scientific Research and Project Coordinator of Selcuk University (Number: BAP 09202041). Experimental part of this work was done in Selcuk University Experimental Medicine Research and Application Center and laboratory applications were done in Selcuk University Meram Medicine Faculthy Department of Histology and Embrylogyen_US
dc.identifier.endpage322en_US
dc.identifier.issn0006-9248en_US
dc.identifier.issn1336-0345en_US
dc.identifier.issue6en_US
dc.identifier.pmid21692405en_US
dc.identifier.startpage318en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26472
dc.identifier.volume112en_US
dc.identifier.wosWOS:000291378700003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCOMENIUS UNIVen_US
dc.relation.ispartofBRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectaortaen_US
dc.subjectdiabetesen_US
dc.subjectintima-media thicknessen_US
dc.subjectTGF beta 1en_US
dc.titleEvaluation of TGF betal expression and comparison the thickness of different aorta layers in experimental diabetesen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu