Synthetic access to new pyridone derivatives through the alkylation reactions of hydroxypyridines with Epoxides

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dc.contributor.authorKocak, Ahmet
dc.contributor.authorKurbanli, Sultan
dc.contributor.authorMalkondu, Sait
dc.date.accessioned2020-03-26T17:18:21Z
dc.date.available2020-03-26T17:18:21Z
dc.date.issued2007
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractGeneral methods for the preparation of a variety of pyridone and oxypyridine derivatives are described. 2-,3-,4-Hydroxy pyridine and 2-pyridinemethanol were alkylated with ethylene-, propylene-, and stryrene-oxide and epichlorohydrin in the presence of different Lewis acids as a catalyst. The best yield of 3a was achieved in the presence of CdI2/BF3 -OEt2. The corresponding pyridone derivatives (3a-d, 7a-d) were obtained from the reaction of 2- and 4-hydroxypyridine with oxiranes in good yields, whereas oxypyridine derivatives (5a-d, 9a,b) were obtained from reactions of 3-hydroxypyridine and 2-pyridinemethanol with oxiranes. Chlorohydrines (3d, 5d, 7d) were easily converted to corresponding epoxy derivatives (10, 11, 12) in basic medium; then amino alcohols (13-17) were obtained from the reaction of these epoxy derivatives with amines.en_US
dc.identifier.doi10.1080/00397910701569254en_US
dc.identifier.endpage3708en_US
dc.identifier.issn0039-7911en_US
dc.identifier.issue19-21en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage3697en_US
dc.identifier.urihttps://dx.doi.org/10.1080/00397910701569254
dc.identifier.urihttps://hdl.handle.net/20.500.12395/21642
dc.identifier.volume37en_US
dc.identifier.wosWOS:000250737500043en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS INCen_US
dc.relation.ispartofSYNTHETIC COMMUNICATIONSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectalkylationen_US
dc.subjectamino alcoholen_US
dc.subjectLewis aciden_US
dc.subjectoxiranesen_US
dc.subjectpyridoneen_US
dc.titleSynthetic access to new pyridone derivatives through the alkylation reactions of hydroxypyridines with Epoxidesen_US
dc.typeArticleen_US

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