Identification of Genotype and Allelic Frequencies of Vitamin D Receptor Gene (Taq1) Polymorphisms in Type 1 Diabetes Mellitus Patients from Turkey

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dc.contributor.authorVural, Hasibe Cingilli
dc.contributor.authorIsler, Orcun
dc.date.accessioned2020-03-26T18:30:41Z
dc.date.available2020-03-26T18:30:41Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractChanges in the DNA or polymorphisms of the VDR cause the protein to bind more or less tightly to 1,25OH. The tighter the vitamin D binds, the stronger and longer lasting the metabolic changes are. Some of the different polymorphisms of the VDR have been associated with an increased risk for Diabetes Mellitus. Recent studies suggest that allelic variations of the vitamin D receptor (VDR) gene can influence Diabetes Mellitus. In brief, the aim of this study was to assess the contribution of these VDR polymorphisms to the susceptibility to Type 1 Diabetes Mellitus in the Turk population. There are several polymorphisms for the VDR gene, but only the three most commonly studied polymorphisms are Taq1, Bsm1 and Fok1 examined. This study suggests that while Taq1 polymorphisms may be functionally different, it may also play a role in serum levels. TT allele of VDR gene has been associated with higher Diabetes Mellitus risk for study on young adults or 100 patients with Type 1 Diabetes Mellitus (DM) (50 women, 50 men) and 120 healthy subjects. The Polymerase chain reaction (PCR) was used for amplification of a 200 bp fragment of the Vitamin D Receptor gene. One study found that TT genotype are overrepresented in Type 1 Diabetes Mellitus patients and those with the TT allele had a 3 fold increase in Type 1 Diabetes Mellitus risk. In addition, the aim of the present study was to adapt PCR amplification, the PCR-RFLP and the most effective DNA isolation method. Taq1 polymorphism indicates susceptibility to Type 1 Diabetes Mellitus in the Turk population. The results indicate that the Taq 1 polymorphism in the VDR gene plays a significant role in protection against T1DM.en_US
dc.description.sponsorshipSelcuk University Archeometry-Biotechnology LaboratorySelcuk University; Scientific Research Foundation of Selcuk University (BAP)Selcuk Universityen_US
dc.description.sponsorshipThis study was partially supported by Selcuk University Archeometry-Biotechnology Laboratory and Scientific Research Foundation of Selcuk University (BAP).en_US
dc.identifier.citationVural, H. C., Isler, O., (2012). Identification of Genotype and Allelic Frequencies of Vitamin D Receptor Gene (Taq1) Polymorphisms in Type 1 Diabetes Mellitus Patients from Turkey. Journal of Applied Biological Sciences. 5(3), 39-42.
dc.identifier.endpage42en_US
dc.identifier.issn0973-6263en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage39en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28123
dc.identifier.volume5en_US
dc.identifier.wosWOS:000304198600004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorVural, Hasibe Cingilli
dc.language.isoenen_US
dc.publisherResearch Journal Biotechnologyen_US
dc.relation.ispartofResearch Journal of Biotechnologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectDiabetes mellitusen_US
dc.subjectgene polymorphismsen_US
dc.subjectVDR geneen_US
dc.titleIdentification of Genotype and Allelic Frequencies of Vitamin D Receptor Gene (Taq1) Polymorphisms in Type 1 Diabetes Mellitus Patients from Turkeyen_US
dc.typeArticleen_US

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