Effect of Oral Glucose Loading on Serum Gastrin Level in Pregnant and Non-Pregnant Women

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dc.contributor.authorGültekin, Fatih
dc.contributor.authorGürbilek, Mehmet
dc.contributor.authorVatansev, Hüsamettin
dc.contributor.authorYaşar, Sulhattin
dc.contributor.authorAköz, Mehmet
dc.contributor.authorÖztürk, Mustafa
dc.date.accessioned2020-03-26T16:37:04Z
dc.date.available2020-03-26T16:37:04Z
dc.date.issued2001
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAim. To evaluate the relationship between the changes in gastrin and insulin serum concentrations after oral glucose loading in pregnant and non-pregnant women. Methods. Thirty women, 12 pregnant and 18 non-pregnant, with normal fasting glucose values were included in the study. Serum concentrations of gastrin, glucose, insulin, and glucagon were analyzed at 0 (t1), 30 (t2) and 60 (t3) minutes after 75 g oral glucose loading. Gastrin, insulin, and glucagon levels were determined by means of radioimmunoassay kits. Results. Serum gastrin concentration in pregnant women increased insignificantly (gastrin median values 57.91, 70.62, and 68.70 for t1, t2, and t3, respectively; Friedman's test, p=0.264). In non-pregnant women gastrin levels insignificantly increased from t1 to t2, but reduced significantly from t2 to t3 (gastrin median values 62.91, 86.92, and 62.25 for t1, t2 and t3, respectively; Bonferroni adjusted Wilcoxon test, p=0.002). Unlike in pregnant women, the changes in gastrin release in non-pregnant women were associated with changes in blood glucose concentrations at t2 and t3, which were induced by oral glucose loading. Glucose median values were 7.48 and 6.43 for t2 and t3, respectively. The insulin release due to the oral glucose loading markedly increased at t2 and t3 (Friedman's test, p<0.001), whereas glucagon release decreased irrespective of pregnancy. Conclusion. Changes in blood glucose concentrations induced by oral glucose loading could influence gastrin release, especially in non-pregnant women. Changes in insulin and glucagon levels induced by oral glucose loading, particularly after 60 minutes, could not be associated with changes in gastrin release.en_US
dc.identifier.citationGürbilek, M., Vatansev, H., Gültekin, F., Yaşar, S., Aköz, M., Öztürk, M., (2001). Effect of Oral Glucose Loading on Serum Gastrin Level in Pregnant and Non-Pregnant Women. Croatian Medical Journal, 42(2), 151-155.
dc.identifier.endpage155en_US
dc.identifier.issn0353-9504en_US
dc.identifier.issue2en_US
dc.identifier.pmid11259736en_US
dc.identifier.startpage151en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17528
dc.identifier.volume42en_US
dc.identifier.wosWOS:000169177100008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGürbilek, Mehmet
dc.institutionauthorVatansev, Hüsamettin
dc.language.isoenen_US
dc.publisherPABST SCIENCE PUBLISHERSen_US
dc.relation.ispartofCroatian Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAdministration, Oralen_US
dc.subjectBlood Glucoseen_US
dc.subjectGlucoseen_US
dc.subjectGlucagonen_US
dc.subjectGastrinen_US
dc.subjectInsulinen_US
dc.subjectPregnancyen_US
dc.titleEffect of Oral Glucose Loading on Serum Gastrin Level in Pregnant and Non-Pregnant Womenen_US
dc.typeArticleen_US

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