Exploring a natural MDR reversal agent: Potential of medicinal food supplement Nerium oleander leaf distillate

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dc.contributor.authorKars M.D.
dc.contributor.authorGündüz U.
dc.contributor.authorÜney K.
dc.contributor.authorBaş A.L.
dc.date.accessioned2020-03-26T18:48:13Z
dc.date.available2020-03-26T18:48:13Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: To investigate the molecular effects of Nerium oleander leaf distillate on paclitaxel and vincristine resistant (MCF-7/Pac and MCF-7/Vinc) cells and sensitive (MCF-7/S) cell lines. Methods: Nerium oleander (N. oleander) leaf extract was obtained by hydrodistillation method. The toxicological effects of N. oleander distillate, previously suggested as medicinal food supplement, on drug resistant cells were evaluated by XTT tests. MDR modulation potential of the plant material was evaluated by flow cytometry and fluorescent microscopy. Paclitaxel and vincristine were applied to the sublines in combination with N. oleander distillate. Results: Fractional inhibitory indices show that N. oleander distillate did not increase the antiproliferative effects of anticancer drugs. N. oleander treatment in to MCF-7/Pac and MCF-7/Vinc did not inhibit P-gp activity and MDR1 gene expression level. Conclusions: As a result it may be suggested that although N. oleander distillate has some medicinal effects as food supplement it may not be suitable as an MDR modulator for drug resistant breast cancer cells. © 2013 Asian Pacific Tropical Biomedical Magazine.en_US
dc.description.sponsorship111S039 11401014 11401014 111S039en_US
dc.description.sponsorship*Corresponding author: Meltem Demirel Kars, Selcuk University, Advanced Technology Research and Application Center-Campus, KONYA-TURKEY. E-mail: meltem@selcuk.edu.tr Tel: 90-3322233438 Foundation Project: Supported by TUBITAK with the project number 111S039 and by the Selcuk University Research Fund with the project number 11401014.en_US
dc.description.sponsorshipThis study was supported by TUBITAK with the project number 111S039 and by the Selcuk University Research Fund with the project number 11401014. Also the distillation method was submitted to Turkish Patent Institute (Application No: 2009/00312) and Patent Coope-ration Treaty (Application No: PCT/TR2009/000013).en_US
dc.identifier.doi10.1016/S2221-1691(13)60130-6en_US
dc.identifier.endpage649en_US
dc.identifier.issn2221-1691en_US
dc.identifier.issue8en_US
dc.identifier.pmid23905023en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage644en_US
dc.identifier.urihttps://dx.doi.org/10.1016/S2221-1691(13)60130-6
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30148
dc.identifier.volume3en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofAsian Pacific Journal of Tropical Biomedicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectFRSA activityen_US
dc.subjectMCF-7en_US
dc.subjectMDR reversalen_US
dc.subjectMedicinal food supplementen_US
dc.subjectNerium oleanderen_US
dc.titleExploring a natural MDR reversal agent: Potential of medicinal food supplement Nerium oleander leaf distillateen_US
dc.typeArticleen_US

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