Effects of vitamin E and prednisolone on some oxidative stress markers in endotoxemic rabbits

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dc.contributor.authorYazar, E
dc.contributor.authorKonyalioglu, S
dc.contributor.authorCol, R
dc.contributor.authorBirdane, YO
dc.contributor.authorBas, AL
dc.contributor.authorElmas, M
dc.date.accessioned2020-03-26T16:48:31Z
dc.date.available2020-03-26T16:48:31Z
dc.date.issued2004
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractEffects of prednisolone (PR) and vitamin E (VE) on oxidative stress and antioxidant systems were investigated in endotoxemic rabbits. Forty rabbits were used and divided into four equal groups. Group I served as the control group. In group II, lipopolysaccharide (LPS, 100 mug/kg/h) was infused for 6 hours, whereas rabbits of groups III and IV received prior treatments with subcutaneous injection of prednisolone (10 mg/kg) (group III) or with intraperitoneous injections of vitamin E (10 mg/kg) for 4 consecutive days (group IV). Serum, liver, heart and kidney samples were obtained at 8 hours after infusion. Malonedialdehyde (MDA), glutathione (GSH) concentrations and superoxide dismutase (SOD), catalase (CAT) activities were spectrophotometrically determined in tissues plus in serum (for MDA). LPS caused statistically significant (p<0.05) increases of MDA and antioxidants in serum and in all tissues. PR and VE significantly (p<0.05) suppressed increases of MDA, SOD, CAT and GSH. As a consequence, prednisolone and vitamin E had protective effects on oxidative stress in endotoxemic rabbits.en_US
dc.identifier.endpage542en_US
dc.identifier.issn0035-1555en_US
dc.identifier.issue11en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage538en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19047
dc.identifier.volume155en_US
dc.identifier.wosWOS:000226041000004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherECOLE NATIONALE VETERINAIRE TOULOUSEen_US
dc.relation.ispartofREVUE DE MEDECINE VETERINAIREen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectvitamin Een_US
dc.subjectprednisoloneen_US
dc.subjectoxidative stressen_US
dc.subjectendotoxemia rabbiten_US
dc.titleEffects of vitamin E and prednisolone on some oxidative stress markers in endotoxemic rabbitsen_US
dc.typeArticleen_US

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