The Investigation of Relationship Between Na+/k +atpase Enzyme Activity, Atp1a1 Gene Polymorphism and C-Peptide in Type 2 Diabetic Patients With Neuropathy

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dc.contributor.authorTopçu, Cemile
dc.contributor.authorGürbilek, Mehmet
dc.contributor.authorAköz, Mehmet
dc.contributor.authorÇora, Tülin
dc.date.accessioned2020-03-26T17:45:45Z
dc.date.available2020-03-26T17:45:45Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjectives: Na+/K+-ATPase is encoded by various genes, of which the ATP1A1 gene is expressed predominantly in peripheral nerves and in erythrocytes. We investigated whether the ATP1A1 polymorphism is associated with Na+/K+-ATPase activity modifications in healthy subjects and in type 2 diabetic patients with polyneuropathy. We also tested whether C-peptide level could influence the relationship between ATP1A1 polymorphism and Na+/K+-ATPase activity. Methods: Na+/K +-ATPase polymorphism has been determined by using polymerasechain reactions and restriction fragment length polymorphism methods. The erythrocyte membrane Na+/K+-ATPase activity measurement was performed with modified Kitao-Hattori method. C-peptide measurements were performed using competitive chemiluminesence enzyme immunoassay method. Results: Na +/K+-ATPase activity was significantly lower in diabetic polyneuropathic patients than in healthy subjects. Correlation between C-peptide levels and Na+/K+-ATPase activity was not detected. All diabetic patients with polyneuropathy and healthy controls were homozygous for the unrestricted allele. Conclusion: Oxidative stress which develops in diabetes causes lipid peroxidation in the membrane and consequently Na +/K+-ATPase activity decreases. Low enzymatic activity leads to decrease in nerve conduction velocity. Therefore, we believe that better regulation of diabetes can abrogate complications and prevent the development of neuropathy.en_US
dc.identifier.citationÇora, T., Aköz, M., Gürbilek, M., Topçu, C., (2009). The Investigation of Relationship Between Na+/k +atpase Enzyme Activity, Atp1a1 Gene Polymorphism and C-Peptide in Type 2 Diabetic Patients With Neuropathy. Turkish Journal of Biochemistry, 34(3), 154-159.
dc.identifier.endpage159en_US
dc.identifier.issn1303-829Xen_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage154en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24084
dc.identifier.volume34en_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorTopçu, C.
dc.institutionauthorGürbilek, M.
dc.institutionauthorAköz, M.
dc.institutionauthorÇora, T.
dc.language.isotren_US
dc.relation.ispartofTurkish Journal of Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectC-peptideen_US
dc.subjectNa+/K+-ATPaseen_US
dc.subjectPolymorphismen_US
dc.titleThe Investigation of Relationship Between Na+/k +atpase Enzyme Activity, Atp1a1 Gene Polymorphism and C-Peptide in Type 2 Diabetic Patients With Neuropathyen_US
dc.title.alternativeTip 2 Diyabetik Nöropatili Hastalarda Eritrosit Zari Na +/k+atpaz Enzim Aktivitesi, Atp1a1 Gen Polimorfizmi Ile C-Peptid Arasındaki Ilişkinin Araştırılmasıen_US
dc.typeArticleen_US

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