The Mechanisms of the Direct Vascular Effects of Sevoflurane on Saphenous Veins in Vitro
Yükleniyor...
Dosyalar
Tarih
2009
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: The purpose of this study was to determine the mechanism of the directs effects of sevoflurane on human veins in vitro. Methods: Dose-response curves were obtained for cumulative doses of sevoflurane(0.5, 1, 1.5 and 2 MAC) on saphenous vein strips precontracted with 5-hydroxytryptamine( 5-HT 10 -6 mol/L) incubated with either Nco-nitroL-arginine-methyl ester(L-NAME)(10-4 mol/L), indomethacine(10-5 mol/L), glibenclamide(10-6 mol/L) or tetraethylammonium(10-4 mol/L) Results: Preincubation of vein strips with tetraethylammonium(TEA, Ca++-activated K+ channel blocker) did not influence the relaxant responses to sevoflurane(p>0.05). L-NAME, indomethacine and glibenclamide reduced the relaxation response to sevoflurane(p<0.05). Conclusion: Our results demonstrated that sevoflurane produces concentration dependent relaxation in human saphenous vein. The relaxant effects of sevoflurane are probably related with activation of nitric oxide synthase, cyclooxygenase and KATP channels pathways.
Açıklama
Anahtar Kelimeler
In vitro, Saphenous vein, Sevoflurane, Vascular effect
Kaynak
European Journal of General Medicine
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
6
Sayı
1
Künye
Ölçer, H. F., Erol, A., Şahin, A. S., Otelcioğlu, Ş., (2009). The Mechanisms of the Direct Vascular Effects of Sevoflurane on Saphenous Veins in Vitro. European Journal of General Medicine, 6(1), 1-5.
