The Mechanisms of the Direct Vascular Effects of Sevoflurane on Saphenous Veins in Vitro

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dc.contributor.authorÖlçer, Havva Feyza
dc.contributor.authorErol, Atilla
dc.contributor.authorŞahin, Ayşe S.
dc.contributor.authorOtelcioğlu, Şeref
dc.date.accessioned2020-03-26T17:45:55Z
dc.date.available2020-03-26T17:45:55Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAim: The purpose of this study was to determine the mechanism of the directs effects of sevoflurane on human veins in vitro. Methods: Dose-response curves were obtained for cumulative doses of sevoflurane(0.5, 1, 1.5 and 2 MAC) on saphenous vein strips precontracted with 5-hydroxytryptamine( 5-HT 10 -6 mol/L) incubated with either Nco-nitroL-arginine-methyl ester(L-NAME)(10-4 mol/L), indomethacine(10-5 mol/L), glibenclamide(10-6 mol/L) or tetraethylammonium(10-4 mol/L) Results: Preincubation of vein strips with tetraethylammonium(TEA, Ca++-activated K+ channel blocker) did not influence the relaxant responses to sevoflurane(p>0.05). L-NAME, indomethacine and glibenclamide reduced the relaxation response to sevoflurane(p<0.05). Conclusion: Our results demonstrated that sevoflurane produces concentration dependent relaxation in human saphenous vein. The relaxant effects of sevoflurane are probably related with activation of nitric oxide synthase, cyclooxygenase and KATP channels pathways.en_US
dc.identifier.citationÖlçer, H. F., Erol, A., Şahin, A. S., Otelcioğlu, Ş., (2009). The Mechanisms of the Direct Vascular Effects of Sevoflurane on Saphenous Veins in Vitro. European Journal of General Medicine, 6(1), 1-5.
dc.identifier.endpage5en_US
dc.identifier.issn1304-3889en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24206
dc.identifier.volume6en_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorÖlçer, Havva Feyza
dc.institutionauthorErol, Atilla
dc.institutionauthorŞahin, Ayşe S.
dc.language.isoenen_US
dc.relation.ispartofEuropean Journal of General Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectIn vitroen_US
dc.subjectSaphenous veinen_US
dc.subjectSevofluraneen_US
dc.subjectVascular effecten_US
dc.titleThe Mechanisms of the Direct Vascular Effects of Sevoflurane on Saphenous Veins in Vitroen_US
dc.typeArticleen_US

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