Effects of cafeic acid phenethyl ester, ellagic acid, sulforaphane and curcumin on diazinon induced damage to the lungs, liver and kidneys in an acute toxicity rat model
Yükleniyor...
Dosyalar
Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Veteriner Fakultesi Dergisi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The aim of this study was to investigate the possible protective efects of cafeic acid phenethyl ester (CAPE), ellagic acid (EA), sulforaphane (SFN) and curcumin (CUR) against the toxic efects of diazinon (DI). Sixty Sprague Dawley rats were randomly divided into 10 groups. Five groups were allocated as control groups comprising unmedicated control, CAPE, EA, SFN and CUR control groups. The remaining five groups were the study groups comprising DI, DI + CAPE, DI + EA, DI + SFN, and DI + CUR groups. The animals were sacrified 24 h after drug administrations. DI caused a decrease in acetyl cholinesterase (AChE) activity (P<0.05) and increases in ?-glutamyltransferase (GGT) and amylase activities. It also damaged the kidney, liver, and lung tissues. The negative efects of DI on these enzymes were confirmed histopathologically. Also, CAPE, EA, SFN and CUR reduced amylase and GGT activities and caused an increase in the AChE activities that were increased due to the toxic efects of DI. Thus, it was determined biochemically and histopathologically that these medication reduced the degenerative toxic efects created by DI in the lung, liver and kidney tissues. These findings led us to believe that CAPE, EA, SFN and CUR may be used as protective medicines in acute DI intoxication.
Açıklama
Anahtar Kelimeler
Cafeic acid phenethyl ester, Curcumin, Diazinon, Ellagic acid, Sulforaphan
Kaynak
Kafkas Universitesi Veteriner Fakultesi Dergisi
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
17
Sayı
6
Künye
Alp, H., Aytekin, I., Esen, H., Basaralı, K., Kul, S. (2011). Effects of Caffeic Acid Phenethyl Ester, Ellagic Acid, Sulforaphane and Curcumin on Diazinon Induced Damage to the Lungs, Liver and Kidneys in An Acute Toxicity Rat Model. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 17(6), 927-933.
