Novel 1,3-thiazolidin-4-one derivatives as promising anti-Candida agents endowed with anti-oxidant and chelating properties

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dc.contributor.authorSecci, Daniela
dc.contributor.authorCarradori, Simone
dc.contributor.authorBizzarri, Bruna
dc.contributor.authorChimenti, Paola
dc.contributor.authorDe Monte, Celeste
dc.contributor.authorMollica, Adriano
dc.contributor.authorRivanera, Daniela
dc.date.accessioned2020-03-26T19:25:23Z
dc.date.available2020-03-26T19:25:23Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPursuing our recent outcomes regarding the antifungal activity of N-substituted 1,3-thiazolidin-4-ones, we synthesized thirty-six new derivatives introducing aliphatic, cycloaliphatic and heteroaromatic moieties at N1-hydrazine connected with C2 position of the thiazolidinone nucleus and functionalizing the lactam nitrogen with differently substituted (NO2, NH2, Cl and F) benzyl groups. These compounds were tested to evaluate their minimum inhibitory concentration (MIC) against several clinical Candida spp. with respect to topical and systemic reference drugs (clotrimazole, fluconazole, ketoconazole, miconazole, tioconazole, amphotericin B). Moreover, anti-oxidant properties were also evaluated by using different protocols including free radical scavenging (DPPH and ABTS), reducing power (CUPRAC and FRAP), metal chelating and phosphomolybdenum assays. Moreover, for the most active derivatives we assessed the toxicity (CC50) against Hep2 human cells in order to characterize them as multi-target agents for fungal infections. (C) 2016 Elsevier Masson SAS. All rights reserved.en_US
dc.description.sponsorshipG. D'Annunzio University of Chietien_US
dc.description.sponsorshipThis work was supported by local grants from "G. D'Annunzio" University of Chieti to Dr. Simone Carradori (2015).en_US
dc.identifier.doi10.1016/j.ejmech.2016.04.012en_US
dc.identifier.endpage156en_US
dc.identifier.issn0223-5234en_US
dc.identifier.issn1768-3254en_US
dc.identifier.pmid27100030en_US
dc.identifier.startpage144en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.ejmech.2016.04.012
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33835
dc.identifier.volume117en_US
dc.identifier.wosWOS:000376837800012en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIERen_US
dc.relation.ispartofEUROPEAN JOURNAL OF MEDICINAL CHEMISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAnti-Candida activityen_US
dc.subjectCytotoxicityen_US
dc.subjectN-benzyl-4-thiazolidinonesen_US
dc.subjectAnti-oxidant agentsen_US
dc.subjectMetal chelating agentsen_US
dc.titleNovel 1,3-thiazolidin-4-one derivatives as promising anti-Candida agents endowed with anti-oxidant and chelating propertiesen_US
dc.typeArticleen_US

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