Incidence and predictors of early seizures in intracerebral haemorrhage and the effect of tranexamic acid

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dc.contributor.authorLaw, Zhe Kang
dc.contributor.authorEngland, Timothy J.
dc.contributor.authorMistri, Amit K.
dc.contributor.authorWoodhouse, Lisa J.
dc.contributor.authorCala, Lesley
dc.contributor.authorDineen, Rob
dc.contributor.authorOzturk, Serefnur
dc.date.accessioned2020-03-26T20:14:42Z
dc.date.available2020-03-26T20:14:42Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIntroduction Seizures are common after intracerebral haemorrhage. Tranexamic acid increases the risk of seizures in non-intracerebral haemorrhage population but its effect on post-intracerebral haemorrhage seizures is unknown. We explored the risk factors and outcomes of seizures after intracerebral haemorrhage and if tranexamic acid increased the risk of seizures in the Tranexamic acid for IntraCerebral Haemorrhage-2 trial. Patients and methods Seizures were reported prospectively up to day 90. Cox regression analyses were used to determine the predictors of seizures within 90 days and early seizures (<= 7 days). We explored the effect of early seizures on day 90 outcomes. Results Of 2325 patients recruited, 193 (8.3%) had seizures including 163 (84.5%) early seizures and 30 (15.5%) late seizures (>7 days). Younger age (adjusted hazard ratio (aHR) 0.98 per year increase, 95% confidence interval (CI) 0.97-0.99; p = 0.008), lobar haematoma (aHR 5.84, 95%CI 3.58-9.52; p < 0.001), higher National Institute of Health Stroke Scale (aHR 1.03, 95%CI 1.01-1.06; p = 0.014) and previous stroke (aHR 1.66, 95%CI 1.11-2.47; p = 0.013) were associated with early seizures. Tranexamic acid did not increase the risk of seizure within 90 days. Early seizures were associated with worse modified Rankin Scale (adjusted odds ratio (aOR) 1.79, 95%CI 1.12-2.86, p = 0.015) and increased risk of death (aOR 3.26, 95%CI 1.98-5.39; p < 0.001) at day 90. Discussion and conclusion: Lobar haematoma was the strongest independent predictor of early seizures after intracerebral haemorrhage. Tranexamic acid did not increase the risk of post-intracerebral haemorrhage seizures in the first 90 days. Early seizures resulted in worse functional outcome and increased risk of death.en_US
dc.description.sponsorshipNIHR HTA grant [11_129_109]; Swiss Heart Foundationen_US
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: NIHR HTA grant (project code 11_129_109) and Swiss Heart Foundation.en_US
dc.identifier.doi10.1177/2396987320901391en_US
dc.identifier.issn2396-9873en_US
dc.identifier.issn2396-9881en_US
dc.identifier.pmid32637645en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.1177/2396987320901391
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37922
dc.identifier.wosWOS:000509178700001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSAGE PUBLICATIONS LTDen_US
dc.relation.ispartofEUROPEAN STROKE JOURNALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectSeizuresen_US
dc.subjectintracerebral haemorrhageen_US
dc.subjecttranexamic aciden_US
dc.subjectrandomised controlled trialen_US
dc.subjectincidenceen_US
dc.titleIncidence and predictors of early seizures in intracerebral haemorrhage and the effect of tranexamic aciden_US
dc.typeArticleen_US

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