Effect of Silybum marianum on acute hepatic damage caused by carbon tetrachloride in rats

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dc.contributor.authorÖztürk, Mustafa
dc.contributor.authorAkdoğan, Mehmet
dc.contributor.authorKeskin, I.
dc.contributor.authorKişioğlu, Ahmet Nesimi
dc.contributor.authorÖztaş, S.
dc.contributor.authorYıldız, K.
dc.date.accessioned2020-03-26T18:25:04Z
dc.date.available2020-03-26T18:25:04Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe study was designed to test the efficiency of of Silybum marianum in different doses to treat carbon tetrachloride (CCl4) induced liver damage. Thirty-five Wistar albino rats were divided randomly into five groups as follows: Control Group: 4 ml saline; CCl4 Group: 4 ml saline plus 2 ml/kg CCl4; 2.5% Infusion Group: 2 ml/kg CCl4 plus 2.5% infusion of Silybum marianum; 5% Infusion Group: 2 ml/kg CCl4 plus 5% infusion of Silybum marianum; 10% Infusion Group: 2 ml/kg CCl4 plus 10% infusion of Silybum marianum. Infusions were given once a day for 5 consequtive days. CCl4 was administered intraperitoneally (2 ml/kg) on days 2 and 3. At the end of the 5th day, animals sacrificed and their bloods were drawn for biochemical tests and liver samples were taken for histopathologic investigation. CCl4 caused to incease in glucose and to decrease in albumin, total cholesterol and trigliceride levels. Silybum Marianum treatment improved these changes. All liver function tests were elevated by of CCl4 administration and than reduced, by Silybum Marianum treatment. CCl4 caused to hepatocyte degeneration, central ven dilatation, congestion, and to increase in the number of Kuppfer cells and histopathological injury scores. Treatment with Silybum marianum infusion showed slightly preventive effect on CCl4 induced liver damage by biochemically and histologically.en_US
dc.identifier.endpage274en_US
dc.identifier.issn0970-938Xen_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage268en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/27952
dc.identifier.volume23en_US
dc.identifier.wosWOS:000306060300021en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSCIENTIFIC PUBLISHERS INDIAen_US
dc.relation.ispartofBIOMEDICAL RESEARCH-INDIAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectSilybum marianumen_US
dc.subjectcarbon tetrachlorideen_US
dc.subjecthepatic damageen_US
dc.subjecthepatoprotectionen_US
dc.titleEffect of Silybum marianum on acute hepatic damage caused by carbon tetrachloride in ratsen_US
dc.typeArticleen_US

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