Identification of Classic and Complex T(15;17) and/or Rar Alpha/Pml Gene Fusion in Apl by Cytogenetic and Dual Color-Fish Techniques

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dc.contributor.authorAcar, H.
dc.contributor.authorDündar, M.
dc.contributor.authorStewart, J.
dc.date.accessioned2020-03-26T16:25:34Z
dc.date.available2020-03-26T16:25:34Z
dc.date.issued1997
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAcute promyelocytic leukemia (APL) is a malignant condition characterized by t(15;17)(q22;q12), which fuses the PML gene on chromosome 15 to the retinoic acid receptor alpha (RAR alpha) gene on chromosome 17. In this study, t(15;17) was identified cytogenetically by using the conventional cytogenetic technique, and its molecular counterpart RAR alpha/PML fusion on chromosome 17 on interphase nuclei was further confirmed by means of dual color- (DC-) fluorescence in situ hybridization (FISH) on serial bone marrow (BM) and peripheral blood (PB) samples from APL patients at different stages of the disease. Overall, our findings indicate that interphase DC-FISH analysis can be a useful technique as an adjunct to conventional cytogenetic investigation for detecting the presence of RAR alpha/PML fusion in APL.en_US
dc.identifier.citationAcar, H., Dündar, M., Stewart, J., (1997). Identification of Classic and Complex T(15;17) and/or Rar Alpha/Pml Gene Fusion in Apl by Cytogenetic and Dual Color-Fish Techniques. Proceedings of the National Science Council, Republic of China. Part B, Life Sciences, 21(2), 54-60.
dc.identifier.endpage60en_US
dc.identifier.issn0255-6596en_US
dc.identifier.issue2en_US
dc.identifier.pmid9276968en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage54en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/16627
dc.identifier.volume21en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAcar, H.
dc.institutionauthorDündar, M.
dc.institutionauthorStewart, J.
dc.language.isoenen_US
dc.relation.ispartofProceedings of the National Science Council, Republic of China. Part B, Life Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleIdentification of Classic and Complex T(15;17) and/or Rar Alpha/Pml Gene Fusion in Apl by Cytogenetic and Dual Color-Fish Techniquesen_US
dc.typeArticleen_US

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