Histological examination of various tissues in rats with hypothyroidism induced by propylthiouracil or thyroidectomy

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dc.contributor.authorMogulkoc, R
dc.contributor.authorCanpolat, L
dc.contributor.authorBaltaci, AK
dc.contributor.authorYilmaz, B
dc.contributor.authorKelestimur, H
dc.date.accessioned2020-03-26T16:27:10Z
dc.date.available2020-03-26T16:27:10Z
dc.date.issued1999
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractDespite the common use of propylthiouracil (PTU) to induce hypothyroidism, it causes degeneration of the thyroid gland, kidney and anterior pituitary tissue. The aim of our study was to determine changes in the liver, thyroid gland, kidney and anterior pituitary from male rats treated with PTU (10 mg/kg/day; for 2 weeks) and in thyroidectomy-induced hypothyroid male rats. Histological examination was performed by light microscopy. Total T3 and T4 levels were determined by radioimmunassay. In both PTU-treated and thyroidectomized groups, plasma T3 and T4 levels were significantly lower than those in the control group. No abnormal changes were observed in the liver tis sue of the hypothyroid rats. There were significant decreases in the epithelial magnitude of degenerated follicular cells in the thyroid tissues of the PTU-treated animals. Furthermore, these were seen in the lumen, which did not contain colloid. There was mononuclear cell infiltration and haemorrhage in the kidney cortex and medulla in both the thyroidectomized and PTU groups. The anterior pituitary in the thyroidectomized and PTU-treated rats showed a diffused hyperplasia. The tissue was locally haemorrhagic, and basophilic cells were frequently localized at the side of the haemorrhage. These findings show that both PTU and thyroidectomy-induced hypothyroidism causes changes in the histology of the kidney, thyroid gland and anterior pituitary. Med Sci Res 27:801-805 (C) 1999 Lippincott Williams & Wilkins.en_US
dc.identifier.endpage805en_US
dc.identifier.issn0269-8951en_US
dc.identifier.issue12en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage801en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/16954
dc.identifier.volume27en_US
dc.identifier.wosWOS:000084305500003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen_US
dc.relation.ispartofMEDICAL SCIENCE RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectanterior pituitaryen_US
dc.subjecthypothyroidismen_US
dc.subjectkidneyen_US
dc.subjectliveren_US
dc.subjectpropylthiouracilen_US
dc.titleHistological examination of various tissues in rats with hypothyroidism induced by propylthiouracil or thyroidectomyen_US
dc.typeArticleen_US

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