Modern and traditional extraction techniques affect chemical composition and bioactivity of Tanacetum parthenium (L.) Sch.Bip

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dc.contributor.authorZengin, Gökhan
dc.contributor.authorCvetanovi?, A.
dc.contributor.authorGaši?, U.
dc.contributor.authorStupar, A.
dc.contributor.authorBulut, G.
dc.contributor.authorŞenkardeş, I.
dc.contributor.authorDoğan, A.
dc.date.accessioned2020-03-26T20:20:52Z
dc.date.available2020-03-26T20:20:52Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractTanacetum parthenium (L.) Sch.Bip (TP), a flowering plant, is famous in traditional medicine to prevent migraine and headache. However, there is currently a dearth of studies to advocate the phytochemical profile and biological propensities of extracts prepared from this plant. This study endeavors to highlight the biological potential of TP extracts prepared by modern (ultrasound-UAE, microwave-MAE and accelerated-ASE extractions) and traditional (maceration and Soxhlet) extraction techniques. The chemical profile of the extracts was established via ultra-high-pressure liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) technique. Sixty different polyphenolic compounds belonging to the classes of phenolic acids, flavonoid glycosides and flavonoid aglycones were recorded in the extracts. Additionally, the quantity of 17 components was measured using appropriate standards and it was found that the modern extraction gave extracts with the higher content of observed compounds than the traditional techniques. Evaluation of antioxidant activity was determined in vitro via five standard assays. The inhibitory potential of TP extracts against key enzymes implicated in the non-communicable diseases such as diabetes (?-amylase and ?-glucosidase), neurodegenerative diseases (acetyl- and butyrylcholinesterase) and skin diseases (tyrosinase), was assessed. Potent antioxidant ability of all TP extract was revealed with a predominance for the extracts yielded using the ASE method. This potent antioxidant activity of the extracts corroborated with the high phenolic (65.05 ± 0.27 mg gallic acid equivalent (GAE)/g extract) and flavonoid contents (55.40 ± 0.52 mg rutin equivalent (RE)/g extract). Tanacetum parthenium extracts also showed significant ?-glucosidase inhibitory activity (1.63–1.67 mmol acarbose equivalent (ACAE)/g extract) and moderate inhibition activity against ?-amylase (0.51-0.56 mmol ACAE/g extract). The extracts also showed potent activity against cholinesterases and tyrosinase. This study tend to validate the use of TP extracts obtained by novel extraction techniques such as ASE, as potent bioactive extracts to be further studied for therapeutic bio-product development. © 2020 Elsevier B.V.en_US
dc.description.sponsorshipMinistarstvo Prosvete, Nauke i Tehnološkog Razvojaen_US
dc.description.sponsorshipThis work was partly supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia.en_US
dc.identifier.doi10.1016/j.indcrop.2020.112202en_US
dc.identifier.issn0926-6690en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.indcrop.2020.112202
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38688
dc.identifier.volume146en_US
dc.identifier.wosWOS:000519335100011en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofIndustrial Crops and Productsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAntioxidanten_US
dc.subjectFeverfewen_US
dc.subjectNovel agentsen_US
dc.subjectPhenolicsen_US
dc.subjectPhytochemicalsen_US
dc.titleModern and traditional extraction techniques affect chemical composition and bioactivity of Tanacetum parthenium (L.) Sch.Bipen_US
dc.typeArticleen_US

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