Both zinc deficiency and supplementation affect plasma melatonin levels in rats

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dc.contributor.authorBediz C.S.
dc.contributor.authorBaltaci A.K.
dc.contributor.authorMogulkoc R.
dc.date.accessioned2020-03-26T16:46:32Z
dc.date.available2020-03-26T16:46:32Z
dc.date.issued2003
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAt physiological levels, zinc and various hormones affect each other reciprocally. Reduction in zinc levels in pinealectomized rats suggests the relation between zinc and melatonin. The effect of both zinc deficiency and supplementation on plasma melatonin levels in rats were investigated in this study. The study was done in Selçuk University, Experimental Medicine Research and Application Center. Twenty-four adult male Sprague Dawley rats were divided into 3 groups. Eight rats were fed with zinc-deficient diet. Zinc supplementation was administered intraperitoneally to 8 rats. The remaining 8 rats were used as controls. All rats sacrificed 3 weeks later. Plasma melatonin and zinc levels were determined. The plasma zinc levels of the zinc-supplemented group were higher than those of the other groups as expected (P<0.01). Similarly, the melatonin levels in the zinc-supplemented group were higher than those in the other groups. A significant decrease was observed in melatonin levels of the zinc-deficient group compared to the control and zinc-supplemented group (P<0.01). The results of this study suggest that zinc deficiency decreases the melatonin levels and zinc supplementation may increase the plasma melatonin levels in rats.en_US
dc.identifier.doi10.1556/APhysiol.90.2003.4.7en_US
dc.identifier.endpage339en_US
dc.identifier.issn0231424Xen_US
dc.identifier.issue4en_US
dc.identifier.pmid14708876en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage335en_US
dc.identifier.urihttps://dx.doi.org/10.1556/APhysiol.90.2003.4.7
dc.identifier.urihttps://hdl.handle.net/20.500.12395/18674
dc.identifier.volume90en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofActa Physiologica Hungaricaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectMelatoninen_US
dc.subjectZincen_US
dc.subjectZinc deficiencyen_US
dc.subjectZinc supplementationen_US
dc.titleBoth zinc deficiency and supplementation affect plasma melatonin levels in ratsen_US
dc.typeArticleen_US

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