Pandemi Döneminde Kan Kültürlerinden İzole Edilen Candida Türlerinin Dağılımı ve Antifungal Duyarlılıklarının Değerlendirilmesi
Dosyalar
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Selçuk Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Hastane kaynaklı enfeksiyonların en önemli sebeplerinden biri olan Candida türleri, kan kültürlerinde en sık izole edilen mantarlardan biridir. Bu çalışmanın amacı pandemi döneminde kan kültürlerinden izole edilen Candida türlerinin dağılımının ve antifungal duyarlılığının değerlendirilmesidir. Selçuk Üniversitesi Tıbbi Mikrobiyoloji Laboratuvurına gönderilen kan kültürleri Ocak 2020-Temmuz 2022 tarihleri arasında geriye dönük olarak incelenmiştir. Tür tanımlaması ve antifungal duyarlılık testleri için VITEK 2 Compact® sistemi kullanılmıştır. Araştırma sonuçlarına göre Candida albicans 36 (%42.8), Candida parapsilosis 24 (%28.6), Candida glabrata 13 (%15.5), Candida tropicalis 5 (%5.9), Candida krusei (Issatchenkia orientalis) 4 (%4.8), Candida guilliermondii (Meyerozyma guilliermondii) 1 (%1.2) ve Candida sphaerica 1 (%1.2) izolatta saptanmıştır. Ayrıca, çalışmada en yüksek direnç caspofungine (%7.4) saptanırken, en düşük antifungal direnç amfoterisin B’ye (%1.8) karşı belirlenmiştir. Sonuç olarak özellikle yenidoğanlarda, yoğun bakım ünitelerinde tedavi gören hastalarda Candida türlerinin tiplendirilmesi ve antifungal duyarlılıklarının belirlenmesi, tedaviye yön vermesi açısından önemlidir.
Candida species, one of the most important causes of hospital-acquired infections, is one of the most frequently isolated fungi in blood cultures. The aim of this study is to evaluate the distribution and antifungal sensitivity of Candida species isolated from blood cultures during the pandemic period. Blood cultures sent to Selçuk University Medical Microbiology Laboratory were retrospectively examined between January 2020 and July 2022. Vitek 2 Compact® system was used for species identification and antifungal susceptibility tests. According to the results of the study Candida albicans 36 (42.8%), Candida parapsilosis 24 (28.6%), Candida glabrata 13 (15.5%), Candida tropicalis 5 (5.9%), Candida krusei (Issatchenkia orientalis) 4 (4.8%) Candida guilliermondii (Meyerozyma guilliermondii) 1 (1.2%) and Candida sphaerica 1 (1.2%) were found to be isolated. In addition, in the study, the highest resistance was determined against caspofungin (7.4%), while the lowest antifungal resistance was determined against amphotericin B (1.8%). In conclusion, it is important to type Candida species and determine their antifungal susceptibility, especially in newborns and patients treated in intensive care units, in terms of guiding the treatment.
Candida species, one of the most important causes of hospital-acquired infections, is one of the most frequently isolated fungi in blood cultures. The aim of this study is to evaluate the distribution and antifungal sensitivity of Candida species isolated from blood cultures during the pandemic period. Blood cultures sent to Selçuk University Medical Microbiology Laboratory were retrospectively examined between January 2020 and July 2022. Vitek 2 Compact® system was used for species identification and antifungal susceptibility tests. According to the results of the study Candida albicans 36 (42.8%), Candida parapsilosis 24 (28.6%), Candida glabrata 13 (15.5%), Candida tropicalis 5 (5.9%), Candida krusei (Issatchenkia orientalis) 4 (4.8%) Candida guilliermondii (Meyerozyma guilliermondii) 1 (1.2%) and Candida sphaerica 1 (1.2%) were found to be isolated. In addition, in the study, the highest resistance was determined against caspofungin (7.4%), while the lowest antifungal resistance was determined against amphotericin B (1.8%). In conclusion, it is important to type Candida species and determine their antifungal susceptibility, especially in newborns and patients treated in intensive care units, in terms of guiding the treatment.
Açıklama
Anahtar Kelimeler
Antifungal duyarlılık, Candida türleri, Kan kültürü, Pandemi, Antifungal sensitivity, Candida species, Blood culture, Pandemic
Kaynak
Mantar Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
13
Sayı
3
Künye
Aydoğan, S., Samadzade, R., Maçin, S., Dağı, H. T., Fındık, D., (2022). Pandemi Döneminde Kan Kültürlerinden İzole Edilen Candida Türlerinin Dağılımı ve Antifungal Duyarlılıklarının Değerlendirilmesi. Mantar Dergisi, 13, (3), 105-110. Doi: 10.30708.mantar.1192975
