Biological activity studies on the aqueous methanol extract of Anchusa undulata L. subsp. hybrida (Ten.) Coutinho

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dc.contributor.authorTaban, Kevser
dc.contributor.authorEruygur, Nuraniye
dc.contributor.authorUstun, Osman
dc.date.accessioned2020-03-26T19:52:59Z
dc.date.available2020-03-26T19:52:59Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe genus Anchusa L. (Boraginaceae) is represented by 15 species in the flora of Turkey. Anchusa species are used traditionally as wound healing and diuretic agent. In addition, some Anchusa species are used as demulcent, expectorant, analgesic, sedative, diaphoretic and antihypertensive purposes. Carminative, antidiabetic, hemostatic and antirheumatical usage is also recorded. The aim of this study is to determine in vitro antioxidant, anti-AChE, anti-BuChE and a-glucosidase activity of methanol extract (Methanol: water = 80: 20, v/v) prepared from roots and aerial parts of Anchusa undulata L. subsp. hybrida (Ten.) Coutinho. Antioxidant activity was evaluated using ABTS and DPPH radical scavenging assay, total phenolic and total flavonoid content. IC50 values for DPPH were 239.47 and 292.04 mu g/mL and for ABTS were calculated as 41.15 and 32.3 mu g/ml. The total phenolic content of root and herbal extract were found as 130.39 and 122.94 mg/g, while flavonoid content as 65.25 and 117.5 mg/g. In the enzyme inhibition studies, the methanol extract showed cholinesterase and alpha-glucosidase enzyme inhibition activities with the increasing concentrations. The significant enzyme inhibition activities are depended on higher amount of phenolic compounds.en_US
dc.identifier.doi10.12991/jrp.2018.75en_US
dc.identifier.endpage364en_US
dc.identifier.issn2630-6344en_US
dc.identifier.issue3en_US
dc.identifier.pmid#YOKen_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage357en_US
dc.identifier.urihttps://dx.doi.org/10.12991/jrp.2018.75
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36363
dc.identifier.volume22en_US
dc.identifier.wosWOS:000445922100003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMARMARA UNIVen_US
dc.relation.ispartofJOURNAL OF RESEARCH IN PHARMACYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectA. undulateen_US
dc.subjectantioxidant activityen_US
dc.subjectanticholinesterase activityen_US
dc.subjectantidiabeticen_US
dc.titleBiological activity studies on the aqueous methanol extract of Anchusa undulata L. subsp. hybrida (Ten.) Coutinhoen_US
dc.typeArticleen_US

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