Measurement of IgA and IgE Concentrations in Canine Keratoconjunctivitis Tears
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Dosyalar
Tarih
2006
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Veteriner oftalmolojide, oküler yangılar ciddi ve sık karsılasılan problemdir. Konjunktivadan lokal olarak salgılanan IgA, öncelikle yangısel olaylara direnç saglanmasında ve hücresel immunitede rol oynar. Çalısmada, 17 köpekten (6 kontrol ve 11 keratokonjunktivitis teshisi konulan) toplanan serum ve göz yası örnekleri kullanıldı. Keratokonjunktivitis teshisi konulan köpeklerin göz muayenelerinde, patolojik akıntı, semosis, hiperemi, hemoraji, amfizem, bazı olgularda lenf foliküllerinde yangı ve asırı göz yası akıntısı gibi bulgular dikkate alındı. Çalısmada, kontrol grubu olarak farklı ırklarda ve cinsiyetlerde, özellikle, sistemik problemleri ve göz hastalıgı olmayan köpekler, seçilerek kullanıldı. Göz yası ve serum sIgA ve IgE seviyeleri nephelometrik yöntem ile ölçüldü. Kontrol grubu ile keratokonjunktivitisli grup arasında sIgA ve IgE seviyelerinde istatistiki farklılıklar bulunmadı. Sonuç olarak, gelecekte yapılacak çalısmalara keratokonjunktivitisli köpeklerden toplanan göz yasında sIgA ve IgE seviyelerinin gösterilmesi hastalıgın erken tanısı, siddeti ve prognozu hakkında bilgi verecegi kanısına varıldı.
Ocular inflammation is a serious and frequently encountered problem in veterinary ophthalmology. Locally acting factors primarily secretory IgA antibodies and cell –mediated immunity are the primary determitants and confering conjunctival resistance to infection. Matched serum, and tear samples were taken from 17 dogs, (6 normal dogs and 11 dogs with keratoconjunctivitis). Clinical signs of conjunctival diseases are show that ocular discharge, chemosis, hyperemia, hemorrhage, emphysema, follicule formation and abnormal swelling. The control dogs used were of unselected breed and sex of both with non-immunemediated orthopaedic disorders, but no history of ocular or systemic disease. All samples measured by nephelometeric system for tear and serum sIgA and IgE levels. There were no significant differences in the level of sIgA and IgE normal and keratoconjunctivitis tear and serum samples. As a conclusion, this study demonstrated that determination of sIgA and IgE levels in tears are of sufficient interest to warrant further research into their biological significance and potential for assessing keratoconjunctivitis severity and progression.
Ocular inflammation is a serious and frequently encountered problem in veterinary ophthalmology. Locally acting factors primarily secretory IgA antibodies and cell –mediated immunity are the primary determitants and confering conjunctival resistance to infection. Matched serum, and tear samples were taken from 17 dogs, (6 normal dogs and 11 dogs with keratoconjunctivitis). Clinical signs of conjunctival diseases are show that ocular discharge, chemosis, hyperemia, hemorrhage, emphysema, follicule formation and abnormal swelling. The control dogs used were of unselected breed and sex of both with non-immunemediated orthopaedic disorders, but no history of ocular or systemic disease. All samples measured by nephelometeric system for tear and serum sIgA and IgE levels. There were no significant differences in the level of sIgA and IgE normal and keratoconjunctivitis tear and serum samples. As a conclusion, this study demonstrated that determination of sIgA and IgE levels in tears are of sufficient interest to warrant further research into their biological significance and potential for assessing keratoconjunctivitis severity and progression.
Açıklama
Anahtar Kelimeler
Veterinerlik, Dogs, IgA, IgE, keratoconjunctivitis, tears, Köpek, keratokonjunktivitis, göz yaşı
Kaynak
Veteriner Cerrahi Derg.
WoS Q Değeri
Scopus Q Değeri
Cilt
12
Sayı
1-2-3-4
Künye
Arıcan, M., Köylü, Ö., Çalım, K. N., Fındık, D., Özkan, K. (2006). Measurement of IgA and IgE Concentrations in Canine Keratoconjunctivitis Tears. Veteriner Cerrahi Dergisi, 12(1-2-3-4), 15-19.
