Gingivitis and Very High IgE Level in a Chronic Granulomatous Disease Patient with Unusual Presentation: A Case Report

Basit Öğe Kaydı
dc.contributor.authorKurt-Sukur, Eda Didem
dc.contributor.authorTurul-Ozgur, Tuba
dc.contributor.authorYaprak, Emre
dc.contributor.authorHakki, Sema
dc.contributor.authorSanal, Ozden
dc.date.accessioned2020-03-26T18:14:47Z
dc.date.available2020-03-26T18:14:47Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractChronic granulomatous disease (CGD) is a rare primary immunodeficiency disease characterized by recurrent bacterial and fungal infections and is due to impaired function of superoxide-producing nicotinamide adenine dinucleotide phosphate oxidase. Patients may have elevated serum IgE levels mainly because of a high incidence of sensitization to Aspergillus species. In addition to a predisposition to infections, patients with CGD might have hyperinflammation presenting itself as chronic inflammatory lesions involving gastrointestinal mucosa, skin, lungs, eyes, and brain. Here, we present a case that mainly presented with chronic gingivitis and very high serum IgE levels and had been referred to our hospital with a probable diagnosis of hyper-IgE syndrome, another congenital immunodeficiency that is also characterized by increased susceptibility to bacterial or fungal infections and very high serum IgE levels. Detailed history of the patient revealed recurrent upper and lower respiratory tract and skin infections. He was diagnosed as having CGD by documenting defective phagocyte superoxide production and the diagnosis was then confirmed by mutation analysis. Family screening revealed that a younger brother was also affected. CGD should be considered in the differential diagnosis of patients with recurrent infections, chronic inflammatory lesions, and high serum IgE levels. These cases emphasize the importance of detailed history taking for diagnosis and family screening for identification of other affected members.en_US
dc.identifier.doi10.1089/ped.2010.0061en_US
dc.identifier.endpage174en_US
dc.identifier.issn2151-321Xen_US
dc.identifier.issn2151-3228en_US
dc.identifier.issue3en_US
dc.identifier.pmid35927869en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage171en_US
dc.identifier.urihttps://dx.doi.org/10.1089/ped.2010.0061
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26523
dc.identifier.volume24en_US
dc.identifier.wosWOS:000295694600009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMARY ANN LIEBERT, INCen_US
dc.relation.ispartofPEDIATRIC ALLERGY IMMUNOLOGY AND PULMONOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleGingivitis and Very High IgE Level in a Chronic Granulomatous Disease Patient with Unusual Presentation: A Case Reporten_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu