Effects of zinc and aprotinin on the healing of ulnar diaphyseal fractures in rabbits
Küçük Resim Yok
Tarih
2018
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
VETERINARNI A FARMACEUTICKA UNIVERZITA BRNO
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The effects of zinc and aprotinin on fracture healing in experimentally induced fractures were investigated by means of histometric analyses and alkaline phosphatase histochemistry. Healthy 54 adult New Zealand White female rabbits were separated into three groups as control, zinc, and aprotinin treatment. The control animals did not receive any medicament; zinc sulphate was given orally to the rabbits in the Zn group for 15 days. Aprotinin was postoperatively infiltrated into the fracture area at the 3rd and 24th h following operation. Immobilization of fracture ends of all groups was similar throughout the experiment. The zinc administered group displayed the highest alkaline phosphatase positive cell level through the experiment. By day 30 after the operation, fibrocartilage and osseous tissues reached the highest levels in the zinc treated group. Based on the observation of augmented osseous tissue formation and increased alkaline phosphatase positive osteoblastic cell activity in the callus, it was conluded that Zn sulphate is a potent stimulator of bone formation by increasing mineralization in the fractured bone segments.
Açıklama
Anahtar Kelimeler
Callus formation, osteoblastic activity, alkaline phosphatase
Kaynak
ACTA VETERINARIA BRNO
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
87
Sayı
2
