Serum Levels of Lipids, Lipoproteins and Apolipoproteins in Patients with Coronary Artery Disease Documented by Angiography
Küçük Resim Yok
Tarih
1996
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Serum Triglyceride (TG), total cholesterol (TC), phospholipid (PL), Apo A-I, Apo B, lipoprotein (a) (Lp(a)), high-density lipoprotein cholesterol (HDL-C,HDL2-C, HDL3-C), low density lipoprotein cholesterol (LDL-C) and free cholesterol (FC) levels of 108 subjects with and without coronary artery disease (CAD) documented by coronary angiography were investigated. Subjects were classified as normal and patients with CAD according to degree of vascular stenosis. Those with ? 50% stenosis in at least one major coronary artery branch were referred as patients with CAD. Patients consisted of 27 women aged 38-73 years and 44 men aged 31-72 years. Controls were 20 women aged 38-77 years and 17 men aged 38-77 years. Men with CAD had significantly higher plasma Lp(a), TC and LDL-C levels than the male controls. They also had significantly lower levels of Apo A-I, HDL-C and HDL2-C. Also, ratios of Apo B/Apo A-I and LDL-C/HDL-C were higher, whereas HDL2-C/HDL-C, HDL-C, TC and HDL2-C/HDL3-C ratios were lower than those of controls. On the other hand plasma Lp(a), Apo B, TC and FC levels of the women with CAD were significantly higher whereas HDL-2-C level was lower compared to the values of the female controls. Ratios of Apo B/Apo A-I and LDL-C/HDL-C were significantly higher, HDL2-C/HDL-C and HDL3-C and HDL2-C/HDL3-C ratio were lower than those of female controls. We concluded that Lp(a) is an independent risk factor for CAD and HDL2-C and HDL2-C/HDL3-C ratio are the best indicators of CAD both in men and women.
Açıklama
Anahtar Kelimeler
Apolipoproteins, Coronary Angiography, Coronary Artery Disease, Lipids, Lipoproteins
Kaynak
Turkish Journal of Medical Sciences
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
26
Sayı
2
Künye
Kocyigit, A., Akkus, I., Vural, H., Gok, H., Caglayan, O., Durmus, B., Celik, M., (1996). Serum Levels of Lipids, Lipoproteins and Apolipoproteins in Patients with Coronary Artery Disease Documented by Angiography. Turkish Journal of Medical Sciences, 26(2), 129.133.
