Significant response of radiation induced CNS toxicity to high dose steroid administration.

Basit Öğe Kaydı
dc.contributor.authorGenc M.
dc.contributor.authorGenc E.
dc.contributor.authorGenc B.O.
dc.contributor.authorKiresi D.A.
dc.date.accessioned2020-03-26T17:05:33Z
dc.date.available2020-03-26T17:05:33Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractTreatment of radiation myelopathy remains a challenge. Supportive and rehabilitative therapy is the mainstay of treatment. This article describes a case of central nervous system (CNS) toxicity of radiation with a progressive improvement in the clinicoradiological picture following high dose steroid treatment. A female patient was admitted to the neurology department of our hospital 7 months after a course of radiotherapy in another centre for lingual epidermoid cancer. Neurological examination revealed a heavy spastic quadriplegia syndrome. On MRI examination, T2 weighted hyperintensities were observed in cerebral and cerebellar peduncles, periventricular regions and medulla spinalis at Th1-Th2 levels. The patient was treated with high dose methylprednisolone, 1 g day(-1) for 5 days (pulse therapy) followed by oral methylprednisolone 80 mg day(-1) for a week, tapered over 3 weeks. Within the first week of pulse therapy, she regained muscle strength of upper limbs against gravity. At the 2 year follow-up, MRI demonstrated obvious regression of the lesions in the medulla and cerebellum with disappearance of contrast enhancement. This case report is notable with the complete disappearance of MRI lesions at the 2 year follow-up after the treatment with high dose steroid.en_US
dc.identifier.endpage199en_US
dc.identifier.issn1748880Xen_US
dc.identifier.issue948en_US
dc.identifier.pmid17213298en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpagee196en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20925
dc.identifier.volume79en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofThe British journal of radiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleSignificant response of radiation induced CNS toxicity to high dose steroid administration.en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu