Screening of PTEN gene mutations in gastric cancer

Basit Öğe Kaydı
dc.contributor.authorYiğin, Aysel Kalaycı
dc.contributor.authorÇora, Tülin
dc.contributor.authorAcar, Hasan
dc.contributor.authorToy, Hatice
dc.contributor.authorKurar, Ercan
dc.date.accessioned2020-03-26T18:58:55Z
dc.date.available2020-03-26T18:58:55Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: It is not exactly defined how many known gastric cancer causative factors cause cancer in stomach lining cells. PTEN gene is an important tumor suppressor gene that is frequently activated in many cancer cells. In this study, we aimed to investigate the molecular changes of PTEN gene in patients with gastric adenocarcinoma. Material and Methods: Forty seven paraffin-embedded tumor tissues from patients diagnosed with gastric adenocarcinoma and adjacent normal tissues were screened for frequency of PTEN mutations using polymerase chain reaction-single strand conformation polymorphism and high resolution melting curve analyses, and DNA sequencing. Results: There were no mutations in exons 3,4,5,6 in the PTEN gene. However, in 8 patients, a single-nucleotide polymorphism (rs1903858) was revealed by sequencing in the junction of intron 1-exon 2, and its clinical significance is not known. Conclusion: There are no data about the function and frequency of this single-nucleotide polymorphism in gastric cancer patients. Therefore, single-nucleotide polymorphism seen in gastric cancer should be evaluated in a larger population of patients to determine its frequency and function in this group. © 2014 by Türkiye Klinikleri.en_US
dc.identifier.doi10.5336/medsci.2013-37635en_US
dc.identifier.endpage110en_US
dc.identifier.issn1300-0292en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage104en_US
dc.identifier.urihttps://dx.doi.org/10.5336/medsci.2013-37635
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31340
dc.identifier.volume34en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkiye Klinikleri Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectDNAen_US
dc.subjectPolymorphismen_US
dc.subjectPTEN phosphohydrolaseen_US
dc.subjectSequence analysisen_US
dc.subjectSingle nucleotideen_US
dc.subjectStomach neoplasmsen_US
dc.titleScreening of PTEN gene mutations in gastric canceren_US
dc.title.alternativeGastrik kanserde PTEN geni mutasyonlarının incelenmesi
dc.typeArticleen_US

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