Dilated cardiomyopathy in a patient with antibody-negative Goodpasture's syndrome and pulmonary relapse.

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dc.contributor.authorSolak Y.
dc.contributor.authorSelcuk N.Y.
dc.contributor.authorPolat I.
dc.contributor.authorAtalay H.
dc.contributor.authorTurkmen K.
dc.date.accessioned2020-03-26T18:06:03Z
dc.date.available2020-03-26T18:06:03Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe Goodpasture's syndrome, also known as anti-GBM disease, is an uncommon disease, responsible for 20% of all cases of rapidly progressive glomerulonephritis. Anti-GBM antibodies are directed against non-collagenous domain (NC-1) of the alpha-3 chain of type IV collagen. When conventional ELISA assays are used, these antibodies can be detected in almost all the patients. Nevertheless, some reports have described antibody-negative relapsing disease. Some aggravating factors, namely, smoking, pulmonary infection and hypervolemia, may expose embedded antigenic target and may be responsible for the relapse. In addition, these antibody-negative relapses also respond to standard treatment, which comprises of plasma exchange, pulse steroids and cyclophosphamide. Herein, we report a patient who presented at the Selcuk University Meram School of Medicine, Meram, Konya, Turkey, with the pulmonary-renal syndrome. He was also found to have idiopathic dilated cardiomyopathy (DCM). To our knowledge, this is the first report describing co-existence of DCM and anti-GBM disease. There is growing evidence showing strong relation of both DCM and anti-GBM disease with HLA. Although not proven, this might have occurred in our patient. In our opinion, volume overload was facilitated by anuria and DCM and led to an antibody-negative pulmonary relapse. The relapse was treated just as the first episode and the patient improved satisfactorily.en_US
dc.identifier.endpage336en_US
dc.identifier.issn1319-2442en_US
dc.identifier.issue2en_US
dc.identifier.pmid20228524en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage332en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/25609
dc.identifier.volume21en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofSaudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleDilated cardiomyopathy in a patient with antibody-negative Goodpasture's syndrome and pulmonary relapse.en_US
dc.typeArticleen_US

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