Valorization of the antioxidant, enzyme inhibition and phytochemical propensities of Berberis calliobotrys Bien. ex Koehne: A multifunctional approach to probe for bioactive natural products

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dc.contributor.authorKhan, Saima
dc.contributor.authorNazir, Mamona
dc.contributor.authorSaleem, Hammad
dc.contributor.authorRaiz, Naheed
dc.contributor.authorSaleem, Muhammad
dc.contributor.authorAnjum, Syed Muhammad Muneeb
dc.contributor.authorZengin, Gökhan
dc.contributor.authorMukhtar, Mahreen
dc.contributor.authorTousif, Muhammad Imran
dc.contributor.authorMahomoodally, Fawzi Mohamad
dc.contributor.authorAhemad, Nafees
dc.date.accessioned2020-03-26T20:19:43Z
dc.date.available2020-03-26T20:19:43Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractChemical composition and pharmacological effects of different extracts of Berberis calliobotrys Bien. ex Koehne were studied. The chemical profile of the methanol, ethyl acetate, n-butanol and aqueous extracts were established by determining their total phenolic and flavonoid contents, besides ultra-high performance liquid chromatography mass spectrometry (UHPLC-MS) of methanol and ethyl acetate extract of Berberis calliobotrys. Antioxidant potential of the extracts was evaluated as inhibition of 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and 2, 2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid (ABTS) free radicals, by reducing power via ferric reducing antioxidant power (FRAP), by cupric reducing antioxidant capacity (CUPRAC), and by phosphomolybdenum and metal chelation assays. Enzyme inhibitory potential of the extracts was also tested against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), alpha-glucosidase, alpha-amylase and tyrosinase. The Bc-W (Berberis calliobotrys aqueous extract) and Bc-M (B. calliobotrys methanol extract) afforded highest phenolic contents with values of 94.34 and 77.70 mgGAE/g extract, respectively, while the Bc-E (Berberis calliobotrys ethyl acetate extract) contained highest flavonoid contents (11.11 mg RE/g extract). UHPLC-MS analysis of Bc-M and Bc-E showed the presence of known secondary metabolites of alkaloid, phenolic, flavonoid, and terpene classes. The Bc-W was the most active in the ABTS, CUPRAC, FRAP and phosphomolybdenum antioxidant assays, whereas for DPPH and metal chelation activities, Bc-M was found to be more potent. The Bc-E and Bc-B (Berberis calliobotrys n-butanol extract) were least active for antioxidant potential. All the extracts showed considerable cholinesterase inhibition, whereas, Bc-E was most potent inhibitor of alpha-amylase, alpha-glucosidase and tyrosinase. It is concluded that B. calliobotrys extracts contained variety of bioactive constituents; antioxidant and enzyme inhibitors thus can be considered as a potential candidate for relevant industrial applications.en_US
dc.identifier.citationKhan, S., Nazir, M., Saleem, H., Raiz, N., Saleem, M., Anjum, S. M. M., Zengin, G., Mukhtar, M., Tousif, M I., Mahomoodally, F. M., Ahemad, N. (2019). Valorization of the Antioxidant, Enzyme Inhibition and Phytochemical Propensities of Berberis calliobotrys Bien. ex Koehne: A Multifunctional Approach to Probe for Bioactive Natural Products. Industrial Crops & Products, 141, 1-7.
dc.identifier.doi10.1016/j.indcrop.2019.111693en_US
dc.identifier.endpage7
dc.identifier.issn0926-6690en_US
dc.identifier.issn1872-633Xen_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1
dc.identifier.urihttps://dx.doi.org/10.1016/j.indcrop.2019.111693
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38379
dc.identifier.volume141en_US
dc.identifier.wosWOS:000496611800007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorZengin, Gökhan
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofINDUSTRIAL CROPS AND PRODUCTSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectUHPLC-MS analysisen_US
dc.subjectAntioxidant potentialen_US
dc.subjectEnzyme inhibitionen_US
dc.subjectBioactive agentsen_US
dc.subjectExtractionen_US
dc.titleValorization of the antioxidant, enzyme inhibition and phytochemical propensities of Berberis calliobotrys Bien. ex Koehne: A multifunctional approach to probe for bioactive natural productsen_US
dc.typeArticleen_US

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