Insight into the biological properties and phytochemical composition of Ballota macrodonta Boiss. et Balansa, - an endemic medicinal plant from Turkey

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dc.contributor.authorUysal, Şengül
dc.contributor.authorAumeeruddy-Elalfi, Zaahira
dc.contributor.authorZengin, Gökhan
dc.contributor.authorAktümsek, Abdurrahman
dc.contributor.authorMocan, Andrei
dc.contributor.authorCustodio, Luisa
dc.contributor.authorNeng, Nuno R.
dc.date.accessioned2020-03-26T19:54:22Z
dc.date.available2020-03-26T19:54:22Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBallota macrodonta Boiss. et Balansa., is a traditionally used endemic medicinal plant used to manage a plethora of diseases in Turkey. Nonetheless, few studies have endeavoured to highlight its therapeutic potential and its phytochemical profile. We hypothesized that B. macrodonta would possess multi-pharmacological propensities and bioactive compounds that would justify its use as a folk remedy. Aerial part of B. macrodonta was assessed for its antioxidant, antimicrobial, and enzymatic inhibitory potential using different extraction solvents. The total bioactive components determination and compound identification using High-Performance Liquid Chromatography with Diode-Array Detection (HPLC-DAD) method were used to correlate the biological properties. HPLC-DAD profile showed the presence of 19 components (e.g. hydroxybenzoic acid, catechin hydrate, vanillic acid, caffeic acid, syringic acid, epicatechin, coumaric acid, ferulic acid, luteolin-7-O-glucoside, rutin, and quercetin). The water and methanolic extracts showed high total phenolic and flavonoid contents, respectively. The overall antioxidant capacity of the water extract was higher than the one of the methanol extract. The extracts showed inhibitory activity against cholinesterases, tyrosinase, alpha-amylase and alpha-glucosidase. The extracts also presented antimicrobial activity against eight Gram positive/negative bacteria (MIC - 0.05-0.15 mg/mL) and eight fungi (MIC - 0.0125-0.20 mg/mL). The presence of active biomolecules with multi-pharmacological properties makes B. macrodonta a potential source of health-promoting compounds that can be exploited as a novel medicinal herbal product.en_US
dc.identifier.doi10.1016/j.indcrop.2018.01.001en_US
dc.identifier.endpage428en_US
dc.identifier.issn0926-6690en_US
dc.identifier.issn1872-633Xen_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage422en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.indcrop.2018.01.001
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36718
dc.identifier.volume113en_US
dc.identifier.wosWOS:000426411800051en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofINDUSTRIAL CROPS AND PRODUCTSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBallotruna crodontaen_US
dc.subjectPhenolicsen_US
dc.subjectAntimicrobialen_US
dc.subjectAntioxidanten_US
dc.subjectEnzyme inhibitoren_US
dc.subjectNatural bioactive agentsen_US
dc.titleInsight into the biological properties and phytochemical composition of Ballota macrodonta Boiss. et Balansa, - an endemic medicinal plant from Turkeyen_US
dc.typeArticleen_US

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