UHPLC-QTOF-MS phytochemical profiling and in vitro biological properties of Rhamnus petiolaris (Rhamnaceae)

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dc.contributor.authorRocchetti, Gabriele
dc.contributor.authorMiras-Moreno, Maria Begona
dc.contributor.authorZengin, Gökhan
dc.contributor.authorŞenkardeş, İsmail
dc.contributor.authorSadeer, Nabeelah Bibi
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.contributor.authorLucini, Luigi
dc.date.accessioned2020-03-26T20:19:41Z
dc.date.available2020-03-26T20:19:41Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractThe genus Rhanmus has a great attention as source of bioactive compounds. So, this work aimed to investigate phytochemical profile and biological activity of water and methanolic extracts of different parts of Rhamnus petiolaris Boiss. & Balansa, namely twigs, leaves, mature and unmature fruits. The in vitro antioxidant activity, enzyme inhibitory properties, along with their polyphenol and anthraquinone profiles were determined by untargeted metabolomics. Results showed that methanolic and aqueous unmature fruit extracts were the most effective 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) scavenger (470.96 mg trolox equivalent (TE)/g and 394.96 mg TE/g, respectively). The aqueous unmature fruit extract displayed the most potent cupric and ferric reducing power and showed the highest total phenolic contents (TPC) (137.17 mg gallic acid equivalent (GAE)/g). The methanolic twig extract showed the highest enzymatic inhibitory property against of alpha-glucosidase, tyrosinase, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). On the basis of the correlation coefficients calculated separately for all experimental parameter pairs, flavonols and anthocyanins highly correlated with DPPH, whereas tyrosols correlated with BChE activity. Multivariate statistics following untargeted metabolomics allowed to describe the differences in polyphenols and anthraquinones, as affected by the extraction solvent used. Mature and unmature fruits were substantially comparable and were affected in a similar way by the extraction conditions, while different profiles were recorded for Rhamnus leaves and twigs. These findings indicate that the recovery efficiencies of specific subclasses of compounds (above all when considering flavonoids, phenolic acids and anthraquinones) as a function of the matrix and extraction chosen, significantly affect the phytochemical profile and biological activity of Rhamnus.en_US
dc.identifier.citationRocchetti, G., Miras-Moreno, M. B., Zengin, G., Senkardes, I., Sadeer, N. B., Mahomoodally, M. F., Lucini, L. (2019). UHPLC-QTOF-MS Phytochemical Profiling and in vitro Biological Properties of Rhamnus petiolaris (Rhamnaceae). Industrial Crops & Products, 142, 1-10.
dc.identifier.doi10.1016/j.indcrop.2019.111856en_US
dc.identifier.issn0926-6690en_US
dc.identifier.issn1872-633Xen_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.indcrop.2019.111856
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38365
dc.identifier.volume142en_US
dc.identifier.wosWOS:000499762200015en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorZengin, Gökhan
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofINDUSTRIAL CROPS AND PRODUCTSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAlpha-glucosidaseen_US
dc.subjectTyrosinaseen_US
dc.subjectBioactive compoundsen_US
dc.subjectMetabolomicsen_US
dc.subjectOrthogonal projection to latent structuresen_US
dc.titleUHPLC-QTOF-MS phytochemical profiling and in vitro biological properties of Rhamnus petiolaris (Rhamnaceae)en_US
dc.typeArticleen_US

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