High sensitive CRP and sICAM-1 can predict Major Adverse Cardiovascular Events: MELEN Study: A Large Turkish Population Based Study

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dc.contributor.authorTurker, Yasin
dc.contributor.authorKayapinar, Osman
dc.contributor.authorDemirin, Hilmi
dc.contributor.authorEroz, Recep
dc.contributor.authorKutlucan, Ali
dc.contributor.authorTurker, Yasemin
dc.contributor.authorBasar, Cengiz
dc.date.accessioned2020-03-26T19:24:29Z
dc.date.available2020-03-26T19:24:29Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: We aimed to evaluate the predictors of major adverse cardiovascular events (MACE) in a prospective population based study. Methods: This study included 153 participants aged>40 years with high and very high cardiovascular risk, and 50 participants aged>40 years with low cardiovascular risk according to the SCORE risk assessment. All the participants underwent a doppler ultrasound examination of carotid intima media thickness (CIMT), echocardiographic examination, ECG recording and various biochemical analyses. High-sensitivity C-reactive protein (hsCRP) was measured with chemiluminescent immunometric assay, serum amyloid-A (SAA) protein, soluble intercellular adhesion molecule-1 (sICAM), apolipoprotein-B (ApoB) were measured with ELISA method. eNOS single-nucleotide polymorphism was detected using polymerase chain reaction and restriction fragment length polymorphism methods. The follow-up was done 36 months after the baseline admission. MACE was defined as cardiovascular mortality or myocardial infarction or stroke. Results: Frequency of MACE was higher in high and very high risk group according to low risk group. There were no significant differences in eNOS gene polymorphisms between the risk groups and control subjects, and no significant association between eNOS gene polymorphisms and MACE was detected. Age, ejection fraction (EF), CIMT, hsCRP, ApoB, sICAM-1, and SAA protein levels were all significantly associated with MACE in univariate logistic regression analyses. Multivariate analyses revealed that age (OR: 1.08, CI: 1.02-1.15, p=0.013), EF (OR: 0.94, CI: 0.89-0.99, p=0.016), hsCRP (OR: 1.36, CI: 1.12-1.67, p=0.003) and sICAM-1 (OR: 81.0, CI: 1.04-6320, p=0.048) levels were the only independent predictors of MACE. Conclusion: Higher age, hsCRP and sICAM-1 levels and lower EF were independent predictors of MACE.en_US
dc.identifier.endpage22en_US
dc.identifier.issn1309-3878en_US
dc.identifier.issue1en_US
dc.identifier.pmid#YOKen_US
dc.identifier.startpage14en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33664
dc.identifier.volume8en_US
dc.identifier.wosWOS:000372103700004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherDUZCE UNIVen_US
dc.relation.ispartofKONURALP TIP DERGISIen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectMajor Adverse Cardiovascular Eventsen_US
dc.subjectSCORE Risken_US
dc.subjecthsCRPen_US
dc.subjectsICAM-1en_US
dc.titleHigh sensitive CRP and sICAM-1 can predict Major Adverse Cardiovascular Events: MELEN Study: A Large Turkish Population Based Studyen_US
dc.typeArticleen_US

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