Asymmetric dimethylarginine and arginine levels in patients with rheumatoid arthritis

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dc.contributor.authorVatansev, Husamettin
dc.contributor.authorOzturk, Bahadir
dc.contributor.authorYilmaz, Sema
dc.contributor.authorSivrikaya, Abdullah
dc.contributor.authorDagli, Mehmet
dc.contributor.authorKiyici, Aysel
dc.contributor.authorUnlu, Ali
dc.date.accessioned2020-03-26T18:41:11Z
dc.date.available2020-03-26T18:41:11Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: Rheumatoid arthritis (RA) is a chronic inflammatory disease and it is associated with premature atherosclerosis development. RA patients have multiple factors to develop premature atherosclerosis. Enhanced asymmetric dimethylarginine (ADMA) is considered as a risk factor for the development of atherosclerosis by inducing endothelial dysfunction. The aim of this study was to investigate the role of asymmetric dimethylarginine, arginine and citrulline levels in patients with RA and their relation to the disease activity parameters for possible role on the disease activity. Methods: 92 patients with RA and 34 healthy controls were included the study. Patients and control blood samples collected for ADMA, arginine and citrulline levels. ADMA, arginine and citrulline levels were measured by pre-column derivatization fluorescence HPLC method. CRP and ESR levels examined on the same day were taken from the patient records. Results: While ADMA levels significantly increased, arginine levels decreased in the patient group. There was no difference in citrulline levels between both groups. Only citrulline and arginine showed a weak positive correlation. ADMA, arginine, and citrulline levels showed no correlation with either biochemical parameters such as CRP or ESR, or disease activity or disease severity. Conclusion: Our study has shown that an increase in ADMA levels with the decrease in arginine levels suggests an increase in arginine turnover to ADMA. Increased ADMA levels can be used for an increased risk for premature development of atherosclerosis in patients with RA. Since high ADMA levels prevent the NO-dependent vasodilatation, a possible role of ADMA in development of premature atherosclerosis may be independent from inflammation.en_US
dc.identifier.doi10.5505/tjb.2013.51523en_US
dc.identifier.endpage175en_US
dc.identifier.issn0250-4685en_US
dc.identifier.issn1303-829Xen_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage169en_US
dc.identifier.urihttps://dx.doi.org/10.5505/tjb.2013.51523
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29252
dc.identifier.volume38en_US
dc.identifier.wosWOS:000323181600007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWALTER DE GRUYTER GMBHen_US
dc.relation.ispartofTURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISIen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectADMAen_US
dc.subjectarginineen_US
dc.subjectcitrullineen_US
dc.subjectCRPen_US
dc.subjectrheumatoid arthritisen_US
dc.titleAsymmetric dimethylarginine and arginine levels in patients with rheumatoid arthritisen_US
dc.typeArticleen_US

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