Effect of laminarin and chitosan gel formulations on the treatment of hydrofluoric acid induced corneal burns in the rabbits

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dc.contributor.authorHatipoglu, F.
dc.contributor.authorOgurtan, Z.
dc.contributor.authorSezer, A. D.
dc.contributor.authorUney, K.
dc.contributor.authorErol, M.
dc.contributor.authorOzdemir, O.
dc.contributor.authorBas, A. L.
dc.date.accessioned2020-03-26T17:26:42Z
dc.date.available2020-03-26T17:26:42Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractCorneal burns were induced in 36 New Zealand white rabbits by instillation in both eyes of 0.05 mL of 2% hydrofluoric acid (HF) for 60 seconds. Following this, the eyes were irrigated with 500 mL isotonic saline (ISOT) and then the rabbits were divided into 4 treatment groups (1) = 9 rabbits each) including: laminarin solution (LS), chitosan hydrogel (CHG), chitosan hydrogel containing laminarin (CHG+L) and ISOT as the control. For each treatment group, one drop of each regimen was instilled 2 times a day and for periods of 2, 7 and 14 days respectively. Thus, 3 rabbits were used for each treatment period in each treatment group. The eyes were clinically examined immediately after the chemical burning and at days 1, 2, 7 and 14 of the follow up periods. The animals were euthanatized at the end of the follow-up periods and eyes were processed for histopathological examination. Clinical and histopathological results revealed that while LS or ISOT was effective, CHG and CHG+L were not effective in the treatment of HF corneal burns. LS had a better therapeutic effect than ISOT. CHG and CHG+L treatment had no accelerating effect on the healing of: corneal erosion throughout the experimental procedures.en_US
dc.identifier.endpage214en_US
dc.identifier.issn0035-1555en_US
dc.identifier.issn2258-0646en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage207en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22339
dc.identifier.volume159en_US
dc.identifier.wosWOS:000256284800005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherECOLE NATIONALE VETERINAIRE TOULOUSEen_US
dc.relation.ispartofREVUE DE MEDECINE VETERINAIREen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectchitosanen_US
dc.subjectlaminarinen_US
dc.subjectisotonic salineen_US
dc.subjectHF induced corneal burnen_US
dc.subjectrabbiten_US
dc.titleEffect of laminarin and chitosan gel formulations on the treatment of hydrofluoric acid induced corneal burns in the rabbitsen_US
dc.typeArticleen_US

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