Characterization of focal liver lesions: Use of mangafodipir trisodium (MnDPDP)-enhanced MR images

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dc.contributor.authorKarabacakoğlu, Aydın
dc.contributor.authorAdıgüzel, Yüksel
dc.contributor.authorKaraköse, Serdar
dc.contributor.authorKayaçetin, Ertuğrul
dc.contributor.authorHaykır, Rahime
dc.date.accessioned2020-03-26T17:05:09Z
dc.date.available2020-03-26T17:05:09Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground/aims: We evaluated the characterization and detection of liver lesions using mangafodipir trisodiutn. Methods: A total of 51 patients with liver lesions [13 hepatocellular carcinomas , 18 metastases, 14 hemangiomas, three cholangiocellular carcinomas, two hydatic cysts, and one focal nodular hyperplasia (FNH)] were examined by unenhanced and mangafodipir trisodium -enhanced MRI. Results: After administration of mangafodipir trisodium by slow intravenous infusion, mangafodipir trisodium -enhanced MRI was performed at 15-30 min and 24 h. The enhancement appeared in normal liver parenchyma and all of the hepatocellular lesions (HCCs and FNH). The lesions in hepatocellular carcinomas patients showed a non-homogeneous enhancement pattern. Non-hepatocellular lesions (hemangiomas, metastases, CCCs) had no enhancement on mangafodipir trisodium -enhanced MRI examinations. The rim-like enhancement pattern was demonstrated in all patients with cholangiocellular carcinomas, and in 14 metastases and 11 hemangiomas. Conclusions: Mangafodipir trisodium -enhanced MRI permits reliable distinction between hepatocellular and non-hepatocellular tumors. Mangafodipir trisodium -enhanced MRI can show more functional and morphologic features of hepatocellular lesions. Some non-hepatocellular lesions which went undetected on unenhanced MRI were visualized after contrast enhancement of the liver. The rim-like enhancement pattern is not specific for metastases. Mangafodipir trisodium -enhanced MRI is safe and well tolerated and may aid in noninvasive diagnosis of liver lesions.en_US
dc.identifier.endpage171en_US
dc.identifier.issn1300-4948en_US
dc.identifier.issue3en_US
dc.identifier.pmid16941248en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage164en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20849
dc.identifier.volume17en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectLiveren_US
dc.subjectMangafodipir trisodiumen_US
dc.subjectMRIen_US
dc.titleCharacterization of focal liver lesions: Use of mangafodipir trisodium (MnDPDP)-enhanced MR imagesen_US
dc.typeArticleen_US

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