Vitamin D-Dependent Rickets: Eight Cases

Basit Öğe Kaydı
dc.contributor.authorCesur, Yasar
dc.contributor.authorYuca, Sevil Ari
dc.contributor.authorBektas, Selcuk
dc.contributor.authorYilmaz, Cahide
dc.contributor.authorDulger, Haluk
dc.contributor.authorTemel, Hayrettin
dc.date.accessioned2020-03-26T19:31:51Z
dc.date.available2020-03-26T19:31:51Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: Vitamin D is essential for bone development and health, and deficiency resulting in rickets and skeletal deformities is seen mainly during rapid growth. Hereditary vitamin D dependent rickets type I and type II rickets is a very rare form of rickets, characterized by 1-alpha-hydroxylase deficiency or end-organ resistance to vitamin D. We aimed to investigate, clinical and laboratory characteristics of eight cases with Vitamin D-dependent rickets (VDRR). Method: The mean age of patients during diagnosis was 2.6 years. Excluding one patient, others were males (87.5%). Results: Mean laboratory values during referral was calcium 7.5 +/- 1,5 mg/dl, phosphorus 4 +/- 1.2 mg/dl, alkaline phosphatase (ALP) 1679 +/- 641 U/L and parathyroid hormone (PTH) 524 +/- 498 pg/ml. Patients received 1.2 mu g/kg/day calcitriol. During follow-ups serum ALP and PTH values of patients turned to normal levels. Conclusion: In rickets, cases with persistent increased serum ALP and PTH levels it will be appropriate to investigate serum 25 (OH) D levels in cases diagnosed with vitamin D-dependent rickets even though hypocalcaemia is absent. Administration of adequate doses of calcitriol in some cases is able to clinical and laboratory values return to normal.en_US
dc.identifier.doi10.15197/ejgm.01464en_US
dc.identifier.endpage20en_US
dc.identifier.issn1304-3889en_US
dc.identifier.issn1304-3897en_US
dc.identifier.issue1en_US
dc.identifier.pmid#YOKen_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage16en_US
dc.identifier.urihttps://dx.doi.org/10.15197/ejgm.01464
dc.identifier.urihttps://hdl.handle.net/20.500.12395/34202
dc.identifier.volume13en_US
dc.identifier.wosWOS:000382752700003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMODESTUM LTDen_US
dc.relation.ispartofEUROPEAN JOURNAL OF GENERAL MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectRicketsen_US
dc.subjectvitamin Den_US
dc.subjectchilden_US
dc.titleVitamin D-Dependent Rickets: Eight Casesen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu