Prevention of Lens Damage Associated with Cigarette Smoke Exposure in Rats by ?- Tocopherol (Vitamin E) Treatment

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dc.contributor.authorAvunduk, A. M.
dc.contributor.authorYardımcı, S.
dc.contributor.authorAvunduk, Mustafa Cihat
dc.contributor.authorKurnaz, L.
dc.contributor.authorAydın, A.
dc.contributor.authorKoçkar, M. C.
dc.contributor.authorDelibaşı, T.
dc.date.accessioned2020-03-26T16:27:39Z
dc.date.available2020-03-26T16:27:39Z
dc.date.issued1999
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPURPOSE. To evaluate the possible protective effect and mechanism of ?- tocopherol (vitamin E) treatment on lens degeneration associated with in vivo exposure to cigarette smoke and to further clarify tile role of iron in cigarette smoke-generated lens damage. METHODS. Twenty-eight male Wistar rats were randomly divided into four equal groups. Rats in groups 3 and 4 were exposed to cigarette smoke for 1 hour each day over 90 consecutive days, and rats in groups 1 and 2 were treated in similar fashion but only exposed to room air. Additionally, vitamin E was given to the rats in groups 2 and 4 via intramuscular route. At the end of the study, both eyes of all the animals were enucleated; one eye was prepared for histopathologic examination, and the fellow eye was used for the measurement of iron and calcium levels. RESULTS. Significantly higher iron and calcium levels were observed in the lenses of group 3 rats than in other groups. Similar comparisons performed between groups 1 and 2, groups 1 and 4, and groups 2 and 4 did not show any significant difference. Distinct histopathologic changes in the anterior lens epithelium, such as hyperplasia, hypertrophy, epithelial multilayering, and the presence of epithelial cells over posterior lens capsule, observed in group 3 rats were not present in other groups. CONCLUSIONS. Cataractogenesis after cigarette smoke exposure was associated with an accumulation of iron and calcium in the rat lens, and vitamin E supplementation protected such accumulations and cataractogenesis.en_US
dc.identifier.citationAvunduk, A. M., Yardımcı, S., Avunduk, M. C., Kurnaz, L., Aydın, A., Koçkar, M. C., Delibaşı, T., (1999). Prevention of Lens Damage Associated with Cigarette Smoke Exposure in Rats by ?- Tocopherol (Vitamin E) Treatment. Investigative Ophthalmology and Visual Science, 40(2), 537-541.
dc.identifier.endpage541en_US
dc.identifier.issn0146-0404en_US
dc.identifier.issue2en_US
dc.identifier.pmid9950617en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage537en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17035
dc.identifier.volume40en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAvunduk, Mustafa Cihat
dc.language.isoenen_US
dc.relation.ispartofInvestigative Ophthalmology and Visual Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titlePrevention of Lens Damage Associated with Cigarette Smoke Exposure in Rats by ?- Tocopherol (Vitamin E) Treatmenten_US
dc.typeArticleen_US

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