The Effect of (Hylan G-F 20) on Bone Metabolism in Dogs with Experimental Osteochondral Defects
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Dosyalar
Tarih
2006
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Dergi Başlığı
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Bu çalısmada, deneysel osteokondral defekt olusturulan köpeklerde intraartiküler Synvisc (Hylan G-F 20) uygulamasının kemik metabolizmasına etkisini amaçlanmıstır. Eklem hastalıklarının teshis ve prognozunda önemli parametre olarak kabul edilen deoksipiridinoline (Dpd) idrarda ve osteokalsin (OC) serum ve sinovyal sıvıda ölçüldü. Osteokondral defekt deneysel olarak sol articulatio genuda olusturuldu. Köpeklerde femurun lateral kondüluslarına matkap yardımı ile 4 mm çapında ve 4 mm derinliginde defektler olusturuldu. Köpeklere, Synvisc (Hylan G-F 20) eklem içine bir hafta ara ile iki defa uygulandı. Serum ve sinovyal sıvıdaki osteokalsin degerleri operasyon öncesi ve sonrasında istatistiki farklılıklar göstermedi. Fakat, saglıklı grup ile deneysel osteokondral defekt olusturulan grupdaki deoksipiridinoline/ kreatinin degerlerinde istatistiki farklılıklar bulundu. Deoksipiridinoline/kreatinin degerleri, köpeklerdeki osteokondral defektlerin sagaltımında ve hastalıgın prognozunun takibinde yararlı parametre olarak kabul edilecegi kanısına varıldı. Sonuç olarak Hylan G-F 20, köpeklerdeki osteokondral defektlerin sagaltımında alternatif yöntemi olarak önerilebilir.
The aim of this study was to determine the effects of intra-articular Synvisc® (Hylan G-F 20) on bone metabolism in dogs with experimental osteochondral defects. Deoxypyridinoline (Dpd) and osteocalcin (OC), which have been used as a diagnostic and prognostic marker for joint disease were measured in urine, sera and synovial fluids (SF) from dogs with experimental osteochondral defects. The left stifle joint was used as the for experimental joint. To defect of 4 mm in diameter and 4 mm in depth, was made in the articular surface of the lateral condyle of 6 dogs by drilling. The dogs were given intraarticular SYNVISC® on two occacions, a week apart. No significant differences in sera and SF osteocalcin were found in either groups before and after operation. However, there was a significant difference in the deoxypyridinoline/creatinine ratio between normal and experimental osteochondral defects urine. This may be useful in the monitoring of therapy and prognosis in dogs with osteochondral defects. The results of study show that Hylan G-F 20 applications could be considered an alternative treatment procedure for osteochondral defects in dogs.
The aim of this study was to determine the effects of intra-articular Synvisc® (Hylan G-F 20) on bone metabolism in dogs with experimental osteochondral defects. Deoxypyridinoline (Dpd) and osteocalcin (OC), which have been used as a diagnostic and prognostic marker for joint disease were measured in urine, sera and synovial fluids (SF) from dogs with experimental osteochondral defects. The left stifle joint was used as the for experimental joint. To defect of 4 mm in diameter and 4 mm in depth, was made in the articular surface of the lateral condyle of 6 dogs by drilling. The dogs were given intraarticular SYNVISC® on two occacions, a week apart. No significant differences in sera and SF osteocalcin were found in either groups before and after operation. However, there was a significant difference in the deoxypyridinoline/creatinine ratio between normal and experimental osteochondral defects urine. This may be useful in the monitoring of therapy and prognosis in dogs with osteochondral defects. The results of study show that Hylan G-F 20 applications could be considered an alternative treatment procedure for osteochondral defects in dogs.
Açıklama
Anahtar Kelimeler
Veterinerlik, Canine, joint disease, deoxypyridinoline, osteocalcin, Köpek, eklem hastalıkları, deoksipiridinoline, osteokalsin
Kaynak
Veteriner Cerrahi Derg.
WoS Q Değeri
Scopus Q Değeri
Cilt
12
Sayı
1-2-3-4
Künye
Arıcan, M., Köylü, Ö., Uyaroğlu, A., Erol, M., Çalım, K. N., (2006). The Effect of (Hylan G-F 20) on Bone Metabolism in Dogs with Experimental Osteochondral Defects. Veteriner Cerrahi Dergisi, 12(1-2-3-4), 20-23.
