Effect of single dose dexamethasone (0.1 mg/kg) on white blood cell counts and serum glucose levels in healthy ewes
Yükleniyor...
Dosyalar
Tarih
2016
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Araştırmanın öncelikli amacı sağlıklı koyunlara tek doz deksametazon (0.1 mg/kg, SC) uygulamasının akyuvar sayısı ve serum glikoz düzeyine etkisini belirlemektedir. Ay-rıca deksametazonun diğer bazı hemogram ve serum biyo-kimyasal parametrelere etkisi de değerlendirilmiştir. Gereç ve Yöntem: Araştırmada 8 adet sağlıklı Akkaraman koyuna 0.1 mg/kg (SC, tek doz) dozunda deksametazon uy-gulandı. Uygulamadan önce (0. saat, kontrol) ve sonraki 4, 8, 12, 24, 36, 48 ve 72. saatlerde kan örnekleri alındı. Akyuvar sayısı, alyuvar sayısı, platelet sayısı, hemogram ve hematok-rit değerleri kan hücresi sayım cihazında ölçülürken, serum glikoz, laktat dehidrogenaz, alkalin fosfataz, total bilirubin, alanin aminotransferaz, aspartat aminotransferaz, gamma glutamiltransferaz, total protein, albümin, kan üre nitrojen, kreatinin, kolesterol, trigliserit, yüksek yoğunluklu lipopro-tein ve düşük yoğunluklu lipoprotein düzeyleri otoanalizör-de ölçüldü. Bulgular: Kontrol (0. saat) zamanla karşılaştırıldığında, dek-sametazonun akyuvar sayısı ve serum glikoz düzeyini yük-selttiği (P0.05) belirlendi ve bu yüksek düzeylerin 48 saat süresince devam ettiği gözlendi. Ayrıca total bilirubin, trig-liserit ve kan üre nitrojen düzeylerinde istatistiki değişimler gözlendi, ancak bu değişimlerin referans aralıklar içinde ol-duğu tespit edildi. Öneri: Koyunlara deksametazon uygulamasının akyuvar sa-yısı ve serum glikoz düzeyini yükseltebileceği ve bu yüksek değerlerin 2-3 gün süresince belirlenebileceği ifade edilebilir.
Aim: Aim of this research was to determine that effect of single dose dexamethasone (0.1 mg/kg, SC) on the white blo-od cell counts and serum glucose levels in healthy ewes. In addition, effects of dexamethasone on the other hemogram and serum biochemical values were evaluated. Materials and Methods: Totally healthy 8 Akkaraman sheep were received with 0.1 mg/kg (SC, single dose) dexametha-sone. Blood samples were taken before (0. hour, control) and after treatments at 4, 8, 12, 24, 36, 48 and 72 hours. White blood cell, red blood cell, platelet, hematocrit and hemog-lobin levels were measured by hemocell counter, whereas serum glucose, lactate dehydrogenase, alkaline phosphata-se, total bilirubin, alanine aminotransferase, aspartate ami-notransferase, gamma glutamyltransferase, total protein, albumin, blood urea nitrogen, creatinine, cholesterol, trigl-yceride, high density lipoprotein and low density lipoprotein levels were determined by auto-analyzer. Results: Dexamethasone increased (P<0.05) white blood cell and glucose levels when compared to Control (0 hour), and higher levels of these values were monitored during 48 hours. In addition, statistically significance changes were de-termined in the total bilirubin, triglyceride and blood urea nitrogen concentrations, but these results were within refe-rence range. Conclusion: It may be stated that dexamethasone increases white blood cell count and glucose levels in sheep and its ef-fect may be determined during 2-3 days after treatments.
Aim: Aim of this research was to determine that effect of single dose dexamethasone (0.1 mg/kg, SC) on the white blo-od cell counts and serum glucose levels in healthy ewes. In addition, effects of dexamethasone on the other hemogram and serum biochemical values were evaluated. Materials and Methods: Totally healthy 8 Akkaraman sheep were received with 0.1 mg/kg (SC, single dose) dexametha-sone. Blood samples were taken before (0. hour, control) and after treatments at 4, 8, 12, 24, 36, 48 and 72 hours. White blood cell, red blood cell, platelet, hematocrit and hemog-lobin levels were measured by hemocell counter, whereas serum glucose, lactate dehydrogenase, alkaline phosphata-se, total bilirubin, alanine aminotransferase, aspartate ami-notransferase, gamma glutamyltransferase, total protein, albumin, blood urea nitrogen, creatinine, cholesterol, trigl-yceride, high density lipoprotein and low density lipoprotein levels were determined by auto-analyzer. Results: Dexamethasone increased (P<0.05) white blood cell and glucose levels when compared to Control (0 hour), and higher levels of these values were monitored during 48 hours. In addition, statistically significance changes were de-termined in the total bilirubin, triglyceride and blood urea nitrogen concentrations, but these results were within refe-rence range. Conclusion: It may be stated that dexamethasone increases white blood cell count and glucose levels in sheep and its ef-fect may be determined during 2-3 days after treatments.
Açıklama
Anahtar Kelimeler
Veterinerlik
Kaynak
Eurasian Journal of Veterinary Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
32
Sayı
3
Künye
Corum, O., Dik, B., Er, A. (2016). Effect of Single Dose Dexamethasone (0.1 Mg/Kg) on White Blood Cell Counts and Serum Glucose Levels in Healthy Ewes. Eurasian Journal of Veterinary Sciences, 32(3), 174-177.
