Reliability of stool antigen tests: Investigation of the diagnostic value of a new immunochromatographic Helicobacter pylori approach in dyspeptic patients

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dc.contributor.authorKorkmaz H.
dc.contributor.authorFindik D.
dc.contributor.authorUgurluoglu C.
dc.contributor.authorTerzi Y.
dc.date.accessioned2020-03-26T19:08:30Z
dc.date.available2020-03-26T19:08:30Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: A diagnosis of H. pylori infection can be made by invasive or non-invasive methods. Several noninvasive diagnostic tests based on the detection of H. pylori stool antigen (HpSA) have been developed. The Genx H. pylori stool antigen card test is a new rapid, non-invasive test that is based on monoclonal immunochromatographic assay. The aim of this study was to determine its sensitivity, specificity, and diagnostic accuracy for diagnosing H. pylori infection in adult patients. Materials and Methods: A total of 162 patients were included in the study. A gastric biopsy was collected for histopathology and rapid urease testing. Stool specimens for HpSA testing were also collected. Patients were considered H. pylori positive if two invasive tests (histological and rapid urease tests) were positive. Results: Using the reference test, 50.6% of the samples were positive for H. pylori infection. The Genx H. pylori antigen test was positive in 19.7% of patients. The sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of the Genx H. pylori antigen test were 51.6%, 96.0%, 88.8%, 76.1%, and 79.0%, respectively. Conclusions: The Genx H. pylori stool antigen card test is a new non-invasive method that is fast and simple to perform but provides less reliable results.en_US
dc.identifier.doi10.7314/APJCP.2015.16.2.657en_US
dc.identifier.endpage660en_US
dc.identifier.issn1513-7368en_US
dc.identifier.issue2en_US
dc.identifier.pmid25684503en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage657en_US
dc.identifier.urihttps://dx.doi.org/10.7314/APJCP.2015.16.2.657
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32857
dc.identifier.volume16en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAsian Pacific Organization for Cancer Preventionen_US
dc.relation.ispartofAsian Pacific Journal of Cancer Preventionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectDiagnostic accuracyen_US
dc.subjectH. pylori antigen testen_US
dc.subjectHelicobacter pylorien_US
dc.subjectSensitivityen_US
dc.subjectSpecificityen_US
dc.titleReliability of stool antigen tests: Investigation of the diagnostic value of a new immunochromatographic Helicobacter pylori approach in dyspeptic patientsen_US
dc.typeArticleen_US

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