In vitro multiple pharmacological targets of Colutea cilicica Boiss. & Balansa against key enzymes linked to neurodegenerative diseases, diabetes, and hyperpigmentation

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dc.contributor.authorUysal, Şengül
dc.contributor.authorCeylan, Ramazan
dc.contributor.authorAktümsek, Abdurrahman
dc.contributor.authorGüler, Gökalp Özmen
dc.contributor.authorPicot, Carene
dc.contributor.authorZengin, Gökhan
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.date.accessioned2020-03-26T19:54:20Z
dc.date.available2020-03-26T19:54:20Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPrevention and treatment of noncommunicable diseases such as neurodegenerative diseases, diabetes, and hyperpigmentation using medicinal plants has attracted increasing attention during the past few decades. In this study, Colutea cilicica Boiss. & Balansa extracts (ethyl acetate, methanol, and water) were evaluated against key enzymes involved in neurodegenerative diseases, diabetes, and hyperpigmentation. The antioxidant (free radical scavenging, reducing power, beta-carotene/linoleic acid, and phosphomolybdenum) and metal chelation properties were also investigated. The methanol extracts of C. cilicica vigorously inhibited the activities of acetylcholinesterase and butyrylcholinesterase (1.33 and 0.68 mg galantamine equivalents (GALAE)/g extract, respectively). It was observed that C. cilicica extracts possessed a higher inhibitory potential for a-glucosidase (2.71-1.23 mmol acarbose equivalents (ACAE)/g extract) than that for a-amylase (0.57-0.12 mmol ACAE/g extract). The water extract of C. cilicica showed potent radical scavenging capacity against DPPH (2, 2-diphenyl-1-picrylhydrazyl) and ABTS (2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (42.46 and 57.70 mg trolox equivalents (TE)/g extract, respectively). Phytochemical determination showed that C. cilicica water extract (17.26 mg rutin equivalents (RE)/g extract) was rich in flavonoids compared with ethyl acetate and methanol extracts (2.78 and 2.83 mg RE/g extract, for the respective extracts). These findings reveal the interesting potential of C. cilicica as a valuable source of phytochemicals that can be used against common noncommunicable diseases, particularly against enzymes involved in neurodegenerative diseases.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [113Z892]en_US
dc.description.sponsorshipThe authors declared that there are no conflicts. This research was also supported by The Scientific and Technological Research Council of Turkey (TUBITAK) (Project Number: 113Z892).en_US
dc.identifier.citationUysal Ş., Ceylan R., Aktümsek A., Güler G. Ö., Picot C., Zengin G., Mahomoodally M. F. (2018). In vitro multiple pharmacological targets of Colutea cilicica Boiss. & Balansa against key enzymes linked to neurodegenerative diseases, diabetes, and hyperpigmentation. ISTANBUL JOURNAL OF PHARMACY, 48(1), 18-24.
dc.identifier.doi10.5152/IstanbulJPharm.2018.396764en_US
dc.identifier.endpage24en_US
dc.identifier.issn0367-7524en_US
dc.identifier.issn2548-0731en_US
dc.identifier.issue1en_US
dc.identifier.pmid#YOKen_US
dc.identifier.startpage18en_US
dc.identifier.urihttps://dx.doi.org/10.5152/IstanbulJPharm.2018.396764
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36708
dc.identifier.volume48en_US
dc.identifier.wosWOS:000433052800004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherISTANBUL UNIV, FAC PHARMACYen_US
dc.relation.ispartofISTANBUL JOURNAL OF PHARMACYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectColutea cilicaen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectdiabetes mellitusen_US
dc.subjectnatural agentsen_US
dc.subjectphytopharmaceuticalsen_US
dc.titleIn vitro multiple pharmacological targets of Colutea cilicica Boiss. & Balansa against key enzymes linked to neurodegenerative diseases, diabetes, and hyperpigmentationen_US
dc.typeArticleen_US

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