Marbofloksasinin kardiyotoksik etkilerinin araştırılması
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Dosyalar
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Selçuk Üniversitesi Veterinerlik Fakülesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Mevcut araştırmanın öncelikli amacı marbofloksasinin kardiyotoksik etkilerini kalp hasarı belirteçleri olan serum troponin I, kreatin kinaz-MB (CK-MB), laktat dehidrogenaz (LDH) ve aspartat aminotransferaz (AST) düzeyleri ölçümü ile belirlemektir. Ayrıca karaciğer fonksiyon [alkalen fosfotaz (ALP), alanin aminotransferaz (ALT), gamma glutamiltransferaz (GGT), total protein], böbrek fonksiyon [kan üre nitrojen (BUN), kreatinin] ve hemogram [akyuvar (WBC), alyuvar (RBC), platelet, hemoglobin, hemotokrit] parametreleri üzerine etkisini belirlemektir. Gereç ve Yöntem: Araştırmada 10 adet Merinos ırkı erkek tokluya marbofloksasin (10 mg/kg/gün, deri altı) 14 gün süresince uygulandı. 0. (Kontrol), 1., 3., 5., 7., 9., 11., 13. ve 15. günler kan örnekleri alındı. Koyun spesifik serum CK-MB ve troponin I düzeyleri ELISA okuyucusunda, serum LDH, AST, ALT, ALP, GGT, total protein, kreatinin ve BUN değerleri otoanalizörde ve hemogram parametreleri kan hücresi sayım cihazında belirlendi. Bulgular: Marbofloksasin uygulamasının kalp hasarı belirteçi troponin I düzeyinde istatistiki olmayan (P>0,05), LDH ve AST düzeylerinde ise istatistiki (P<0,05) yükselmelere neden olduğu belirlendi. Marbofloksasin uygulamasının karaciğer fonksiyon parametreleri üzerine olumsuz etkisi belirlenmezken (P>0,05), böbrek fonksiyon parametrelerinden BUN düzeyinde artışlara (P<0,05), kreatinin düzeyinde ise istatistiki (P<0,05) dalgalanmalara neden olduğu belirlendi. Hemogram parametrelerinde ise referans değerlere yakın geçici düşmeler (P<0,05) gözlendi. Öneri: Koyunlara yüksek dozlarda uzun süreli marbofloksasin kullanılması gerektiğinde kardiyotoksisite açısından dikkatli olunması gerektiği ifade edilebilir. Ancak marbofloksasinin kardiyotoksik etkileri histopatolojik olarak doğrulanmalıdır.
Aim: The primary objective of the present research is to determine the cardiotoxic effect of marbofloxacin by measuring of serum troponin I, creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) levels which are cardiotoxic damage markers. In addition, it is to determine the effects of marbofloxacin on the liver function [alkaline phosphatase (ALP), alanine aminotransferase (ALT), gamma glutamyltransferase (GGT), total protein], renal function [blood urea nitrogen (BUN, creatinine] and hemogram [white blood cell (WBC), red blood cell (RBC), platelet, hemoglobin, hematocrit] parameters. Materials and Methods: In the study, 10 Merino yearling received marbofloxacin (10 mg/kg/day, subcutan) for 14 days. Blood samples were taken on day 0 (control), 1, 3, 5, 7, 9, 11, 13 and 15 days. Sheep specific serum CK-MB and troponin I levels were measured with ELISA reader, while serum LDH, AST, ALT, ALP, GGT, total protein, creatinine and BUN values were determined with autoanalyser. Hemogram parameters were determined with hemocell counters, as well. Results: Marbofloxacin increased cardiac damage markers which were troponin I, not statistically significant (P>0,05), LDH and AST levels, statistically significant (P<0,05). While marbofloxacin did not cause (P<0,05) any adverse effect on liver function parameters, it caused (P<0,05) increase BUN levels and fluctuations in creatinine levels which were renal function values. In hemogram parameters, it caused (P <0,05) temporary decreases close to the reference values. Conclusion: It can be stated that the when sheep should be treated with high doses of long-term marbofloxacin, cardiotoxicity should be taken with caution. However, cardiotoxic effects of marbofloxacin should be confirmed histopathologically
Aim: The primary objective of the present research is to determine the cardiotoxic effect of marbofloxacin by measuring of serum troponin I, creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) levels which are cardiotoxic damage markers. In addition, it is to determine the effects of marbofloxacin on the liver function [alkaline phosphatase (ALP), alanine aminotransferase (ALT), gamma glutamyltransferase (GGT), total protein], renal function [blood urea nitrogen (BUN, creatinine] and hemogram [white blood cell (WBC), red blood cell (RBC), platelet, hemoglobin, hematocrit] parameters. Materials and Methods: In the study, 10 Merino yearling received marbofloxacin (10 mg/kg/day, subcutan) for 14 days. Blood samples were taken on day 0 (control), 1, 3, 5, 7, 9, 11, 13 and 15 days. Sheep specific serum CK-MB and troponin I levels were measured with ELISA reader, while serum LDH, AST, ALT, ALP, GGT, total protein, creatinine and BUN values were determined with autoanalyser. Hemogram parameters were determined with hemocell counters, as well. Results: Marbofloxacin increased cardiac damage markers which were troponin I, not statistically significant (P>0,05), LDH and AST levels, statistically significant (P<0,05). While marbofloxacin did not cause (P<0,05) any adverse effect on liver function parameters, it caused (P<0,05) increase BUN levels and fluctuations in creatinine levels which were renal function values. In hemogram parameters, it caused (P <0,05) temporary decreases close to the reference values. Conclusion: It can be stated that the when sheep should be treated with high doses of long-term marbofloxacin, cardiotoxicity should be taken with caution. However, cardiotoxic effects of marbofloxacin should be confirmed histopathologically
Açıklama
Anahtar Kelimeler
Marbofloksasin, kardiyotoksisite, Marbofloxacin, cardiotoxicity
Kaynak
Eurasian Journal of Veterinary Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
35
Sayı
2
Künye
Coşkun, D., Dik, B., Korkmaz, Y., Canbar, R., Er, A., Yazar, E. (2019). Marbofloksasinin kardiyotoksik etkilerinin araştırılması. Eurasian Journal of Veterinary Sciences, 35 (2), 56-61. DOI: 10.15312/EurasianJVetSci.2019.223
