A novel colorimetric/fluorometric dual-channel sensor based on phenolphthalein and Bodipy for Sn (II) and Al (III) ions in half-aqueous medium and its applications in bioimaging

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dc.contributor.authorGul A.
dc.contributor.authorOguz M.
dc.contributor.authorKursunlu A.N.
dc.contributor.authorYilmaz M.
dc.date.accessioned2020-03-26T20:20:40Z
dc.date.available2020-03-26T20:20:40Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to develop a new colorimetric and fluorometric chemosensor for Sn (II) & Al(III) detection in half aqueous medium. A new probe containing Bodipys, appended on phenolphthalein (PP-B) was synthesized with multi-step reactions. The structure of intermediate products and target compound was characterized with spectroscopic techniques. The absorption and emission properties of the synthesized PP-B probe were investigated in detail and it was deduced that PP-B probe possesses a specifically real-time, fluorometric and colorimetric response to Sn(II) and Al(III) in H2O/acetone (v/v: 1:1). The selectivity of the probe was checked in the presence of competing metal ions [Al(III), Zn(II), Cu(II), Cd(II), Fe(II), Sn(II), Hg(II), Co(II), Pb(II), Ga(III), Cr(III)]. It was found that there was a marginal difference in fluorescence response of PP-B towards Sn (II) and Al (III) in the presence of competing metal ions. Under the optimized conditions, 1:2 (ligand:metal) stoichiometries were obtained by Job's plot for Sn(II) and Al(III) complexes, respectively. Cell viability study was carried out to check the applicability of probe in human cancer cell lines. Fluorescence images of the probe (PP-B) in human lung cancer cell lines with XTT (sodium 3?-[1-[(phenylamino)-carbony]-3,4-tetrazolium]-bis(4-methoxy-6-nitro)benzene-sulfonic acid hydrate) test to detect the presence of Sn (II) and Al (III) were acquired by using a confocal laser scanning microscope. © 2020 Elsevier Ltden_US
dc.description.sponsorshipWe thank the Research Foundation of Selcuk University for financial support of this work.en_US
dc.identifier.doi10.1016/j.dyepig.2020.108221en_US
dc.identifier.issn0143-7208en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.dyepig.2020.108221
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38639
dc.identifier.volume176en_US
dc.identifier.wosWOS:000519335300029en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofDyes and Pigmentsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAluminum ionen_US
dc.subjectBodipyen_US
dc.subjectCell imagingen_US
dc.subjectColorimetricen_US
dc.subjectCytotoxicityen_US
dc.subjectFluorescenten_US
dc.subjectPhenolphthaleinen_US
dc.subjectTin ionen_US
dc.titleA novel colorimetric/fluorometric dual-channel sensor based on phenolphthalein and Bodipy for Sn (II) and Al (III) ions in half-aqueous medium and its applications in bioimagingen_US
dc.typeArticleen_US

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