Investigation of the cardiotoxicity of imidocarb in lambs
Küçük Resim Yok
Tarih
2011
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
ECOLE NATIONALE VETERINAIRE TOULOUSE
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aim of this study was to determine the cardiotoxic side effect of imido carb in sheep. Imidocarb was administered subcutaneously at the dose of 2.4 mg/kg to healthy ten lambs and blood samples were obtained immediately before and 6 hours after the drug administration. Serum cardiac damage markers I troponin I and myoglobin concentrations. CK-MB (creatine kinase isotype MB). LDH (lactate deshydrogenase) and AST (aspartate aminotransferase)]. some renal [creatinine and BUN (blood urea nitrogen)] and liver I total protein. albumin. lactate. glucose concentrations and ALT (alanine aminotranferase). ALP (alkaline phosphatase). GGT (gamma-glutamyl transferase) activities] markers and the general lipid metabolism (amylase activity. cholesterol. triglyceride. HDL concentrations) were explored as well as the venous blood gas parameters (pH. haematocrit. haemoglobinemia. pCO(2)). total carbon dioxide. bicarbonate concentrations) and base excesses. oxygen saturation. Na. K and Ca concentrations). The imidocarb treatment has induced significant increases of CK-MB activities. and significant reductions of the haematocrit. haemoglobinemia. sodium and calcium concentrations and of pCO(2), tCO(2). alkaline store and base excesses. These results suggest that the drug exerted some moderate elicits on the heart leading to a tendency for respiratory acidosis and that the risk for imidocarb cardiotoxicity remained moderate hut not negligible.
Açıklama
Anahtar Kelimeler
Imidocarb, lamb, troponin I, creatine kinase-MB, cardiotoxicity, respiratory acidosis
Kaynak
REVUE DE MEDECINE VETERINAIRE
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
162
Sayı
1
